Ezetimibe/simvastatin

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Ezetimibe/simvastatin

Combination of
Ezetimibe	via Niemann-Pick C1-Like 1 protein
Simvastatin	Statin HMG-CoA reductase inhibitor
Clinical data
Pronunciation	/ɛˈzɛtɪmɪb ˌsɪmvəˈstætɪn/
Trade names	Vytorin (US), Inegy (EU)
License data	US DailyMed: Vytorin
Routes of administration	By mouth
ATC code	C10BA02 (WHO)
Legal status
Legal status	AU: S4 (Prescription only)[1] US: ℞-only In general: ℞ (Prescription only)
Identifiers
CAS Number	163222-33-1 Y 79902-63-9 Y
PubChem CID	9832423
DrugBank	DB00973 Y DB00641
ChemSpider	21106308 Y
UNII	EOR26LQQ24 AGG2FN16EV Y
KEGG	D10257 N
CompTox Dashboard (EPA)	DTXSID80196177
Chemical and physical data
Formula	C49H59F2NO8
Molar mass	828.007 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCC(C)(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C.C1=CC(=CC=C1C2C(C(=O)N2C3=CC=C(C=C3)F)CCC(C4=CC=C(C=C4)F)O)O
InChI InChI=1S/C25H38O5.C24H21F2NO3/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19;25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3;1-12,21-23,28-29H,13-14H2/t15-,16-,18+,19+,20-,21-,23-;21-,22+,23-/m01/s1 Key:PNAMDJVUJCJOIX-IUNFJCKHSA-N
NY (what is this?)  (verify)

Ezetimibe/simvastatin is a drug combination used for the treatment of dyslipidemia. It is a combination of ezetimibe (known as Zetia in the United States) and the statin drug simvastatin (known as Zocor in the US).

Ezetimibe reduces blood cholesterol by acting at the brush border of the small intestine and inhibiting the absorption of cholesterol, leading to a decrease in the delivery of intestinal cholesterol to the liver.

Simvastatin is an HMG-CoA reductase inhibitor or statin. It works by blocking an enzyme that is necessary for the body to make cholesterol. Generic versions were approved in 2017.^[2] The combination preparation is marketed by Merck & Co. under the trade names Vytorin in the US and Inegy in the European Union. In 2018, it was the 349th most commonly prescribed medication in the United States, with more than 800 thousand prescriptions.^[3]