Ezrin

EZR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4RM8, 4RMA, 4RM9, 1NI2
Identifiers
Aliases	EZR, CVIL, CVL, HEL-S-105, VIL2, Ezrin
External IDs	OMIM: 123900; MGI: 98931; HomoloGene: 55740; GeneCards: EZR; OMA:EZR - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	158,819,368 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	7,050,183 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; bronchial epithelial cell; ; ganglionic eminence; ; nasal epithelium; ; olfactory zone of nasal mucosa; ; mucosa of paranasal sinus; ; tendon of biceps brachii; ; right adrenal cortex; ; right uterine tube; ; jejunal mucosa;
	Top expressed in
	epithelium of stomach; ; mucous cell of stomach; ; left colon; ; epithelium of small intestine; ; intestinal villus; ; ileum; ; seminal vesicula; ; Ileal epithelium; ; pyloric antrum; ; Epithelium of choroid plexus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; protein-containing complex binding; cytoskeletal protein binding; protein kinase A regulatory subunit binding; protein kinase A catalytic subunit binding; S100 protein binding; actin filament binding; protein binding; cell adhesion molecule binding; microtubule binding; ATPase binding; actin binding; RNA binding; cadherin binding; protein C-terminus binding; disordered domain specific binding; protein kinase A binding; identical protein binding;
Cellular component	cytoplasm; cytosol; endosome; membrane; focal adhesion; T-tubule; ruffle; Schwann cell microvillus; ruffle membrane; actin cytoskeleton; perinuclear region of cytoplasm; cytoskeleton; cell projection; cytoplasmic side of apical plasma membrane; myelin sheath; microvillus; microspike; apical plasma membrane; membrane raft; extracellular exosome; microvillus membrane; ciliary basal body; filopodium; cortical cytoskeleton; plasma membrane; apical part of cell; astrocyte projection; intracellular anatomical structure; cell cortex; brush border; actin filament; TCR signalosome; cell periphery; cell body; vesicle; plasma membrane raft; uropod; basolateral plasma membrane; immunological synapse; cell tip; fibrillar center; extracellular space; extrinsic component of membrane; protein-containing complex;
Biological process	leukocyte cell-cell adhesion; regulation of organelle assembly; sphingosine-1-phosphate receptor signaling pathway; negative regulation of p38MAPK cascade; actin filament bundle assembly; establishment of epithelial cell apical/basal polarity; positive regulation of multicellular organism growth; astral microtubule organization; cellular response to cAMP; establishment of endothelial barrier; microvillus assembly; negative regulation of T cell receptor signaling pathway; gland morphogenesis; cortical microtubule organization; positive regulation of protein localization to early endosome; positive regulation of early endosome to late endosome transport; intestinal D-glucose absorption; establishment or maintenance of apical/basal cell polarity; regulation of NIK/NF-kappaB signaling; epithelial cell differentiation; regulation of actin cytoskeleton organization; negative regulation of transcription by RNA polymerase II; positive regulation of protein secretion; membrane to membrane docking; regulation of cell shape; protein kinase A signaling; establishment of centrosome localization; phosphatidylinositol-mediated signaling; regulation of cell size; actin cytoskeleton reorganization; filopodium assembly; receptor internalization; terminal web assembly; axon guidance; positive regulation of gene expression; negative regulation of ERK1 and ERK2 cascade; protein localization to cell cortex; regulation of microvillus length; protein localization to plasma membrane; positive regulation of protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	7430
	22350
	ENSG00000092820
	ENSMUSG00000052397
	P15311
	P26040
	NM_001111077; NM_003379
	NM_009510
	NP_001104547; NP_003370
	NP_033536
	Wikidata
View/Edit Human	View/Edit Mouse

Ezrin also known as cytovillin or villin-2 is a protein that in humans is encoded by the EZR gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000092820 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052397 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gould KL, Bretscher A, Esch FS, Hunter T (December 1989). "cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1". EMBO J. 8 (13): 4133–42. doi:10.1002/j.1460-2075.1989.tb08598.x. PMC 401598. PMID 2591371.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000092820 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052397 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2591371-5] Gould KL, Bretscher A, Esch FS, Hunter T (December 1989). "cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1". EMBO J. 8 (13): 4133–42. doi:10.1002/j.1460-2075.1989.tb08598.x. PMC 401598. PMID 2591371.

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