F2RL3

F2RL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ZPK, 3QDZ
Identifiers
Aliases	F2RL3, PAR4, F2R like thrombin/trypsin receptor 3, F2R like thrombin or trypsin receptor 3
External IDs	OMIM: 602779; MGI: 1298207; HomoloGene: 36148; GeneCards: F2RL3; OMA:F2RL3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	16,892,606 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	73,490,502 bp
RNA expression pattern
	Top expressed in
	right lung; ; upper lobe of left lung; ; left lobe of thyroid gland; ; subcutaneous adipose tissue; ; islet of Langerhans; ; right lobe of thyroid gland; ; lactiferous gland; ; monocyte; ; body of stomach; ; transverse colon;
	Top expressed in
	left lobe of liver; ; right lobe of liver; ; vasculature; ; vasculature of organ; ; choroid plexus; ; embryo; ; spleen; ; yolk sac; ; quadriceps femoris muscle; ; placenta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	thrombin-activated receptor activity; signal transducer activity; G protein-coupled receptor activity;
Cellular component	integral component of membrane; extracellular region; integral component of plasma membrane; membrane; plasma membrane;
Biological process	platelet activation; hemostasis; phospholipase C-activating G protein-coupled receptor signaling pathway; thrombin-activated receptor signaling pathway; positive regulation of release of sequestered calcium ion into cytosol; platelet dense granule organization; response to wounding; signal transduction; blood coagulation; positive regulation of Rho protein signal transduction; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	9002
	14065
	ENSG00000127533
	ENSMUSG00000050147
	Q96RI0
	O88634
	NM_003950
	NM_007975
	NP_003941
	NP_032001
	Wikidata
View/Edit Human	View/Edit Mouse

Protease-activated receptor 4 (PAR-4), also known as coagulation factor II (thrombin) receptor-like 3, is a protein that in humans is encoded by the F2RL3 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127533 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050147 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: F2RL3 coagulation factor II (thrombin) receptor-like 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000127533 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050147 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: F2RL3 coagulation factor II (thrombin) receptor-like 3".

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