FARSA (gene)

FARSA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFARSA, CML33, FARSL, FARSLA, FRSA, PheHA, phenylalanyl-tRNA synthetase alpha subunit, phenylalanyl-tRNA synthetase subunit alpha, RILDBC2
External IDsOMIM: 602918; MGI: 1913840; HomoloGene: 3280; GeneCards: FARSA; OMA:FARSA - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004461

NM_025648

RefSeq (protein)

NP_004452

NP_079924

Location (UCSC)Chr 19: 12.92 – 12.93 MbChr 8: 85.58 – 85.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phenylalanyl-tRNA synthetase alpha chain is an enzyme that in humans is encoded by the FARSA gene.[5][6]

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of regulated expression[6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000179115Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003808Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sen S, Zhou H, Ripmaster T, Hittelman WN, Schimmel P, White RA (Jul 1997). "Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent". Proc Natl Acad Sci U S A. 94 (12): 6164–9. Bibcode:1997PNAS...94.6164S. doi:10.1073/pnas.94.12.6164. PMC 21020. PMID 9177188.
  6. ^ a b "Entrez Gene: FARSA phenylalanyl-tRNA synthetase, alpha subunit".