The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinityreceptor for the Fc region of immunoglobulin E (IgE), an antibodyisotype involved in allergy disorders and parasite immunity. FcεRI is a tetrameric receptor complex that binds Fc portion of the ε heavy chain of IgE.[1] It consists of one alpha (FcεRIα – antibody binding site), one beta (FcεRIβ – which amplifies the downstream signal), and two gamma chains (FcεRIγ – the site where the downstream signal initiates) connected by two disulfide bridges on mast cells and basophils. It lacks the beta subunit on other cells. It is constitutively expressed on mast cells and basophils[2] and is inducible in eosinophils.
^Kumar, Vinay; Abbas, Abul K.; Aster, Jon (2012-05-01). Robbins Basic Pathology (9 ed.). Saunders.
^Pawankar R (February 2001). "Mast cells as orchestrators of the allergic reaction: the IgE-IgE receptor mast cell network". Current Opinion in Allergy and Clinical Immunology. 1 (1): 3–6. doi:10.1097/00130832-200102000-00002. PMID11964662.
