FGF10

FGF10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1NUN
Identifiers
Aliases	FGF10, fibroblast growth factor 10
External IDs	OMIM: 602115; MGI: 1099809; HomoloGene: 3284; GeneCards: FGF10; OMA:FGF10 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	44,389,706 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	118,928,651 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; synovial joint; ; canal of the cervix; ; ectocervix; ; synovial membrane; ; left uterine tube; ; vagina; ; gastric mucosa; ; caput epididymis; ; muscle layer of sigmoid colon;
	Top expressed in
	otic pit; ; muscle layer of seminal vesicle; ; hair; ; lamina propria of vagina; ; spermatid; ; dentate gyrus of hippocampal formation granule cell; ; pituitary stalk; ; zygote; ; primordial pancreas; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	heparin binding; type 2 fibroblast growth factor receptor binding; growth factor activity; protein binding; fibroblast growth factor receptor binding; chemoattractant activity; protein tyrosine kinase activity; 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
Cellular component	extracellular region; nucleus; cell surface; extracellular matrix; plasma membrane; extracellular space; collagen-containing extracellular matrix;
Biological process	bud outgrowth involved in lung branching; limb bud formation; organ growth; semicircular canal morphogenesis; embryonic pattern specification; bud elongation involved in lung branching; positive regulation of canonical Wnt signaling pathway; muscle cell fate commitment; tear secretion; positive regulation of Ras protein signal transduction; positive regulation of urothelial cell proliferation; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; limb development; radial glial cell differentiation; female genitalia morphogenesis; mesonephros development; odontogenesis of dentin-containing tooth; prostatic bud formation; blood vessel remodeling; regulation of saliva secretion; angiogenesis; establishment of mitotic spindle orientation; positive regulation of ERK1 and ERK2 cascade; embryonic digestive tract morphogenesis; animal organ morphogenesis; hair follicle morphogenesis; metanephros development; lung saccule development; lung epithelium development; positive regulation of Notch signaling pathway; negative regulation of cell population proliferation; branch elongation involved in salivary gland morphogenesis; branching involved in salivary gland morphogenesis; positive regulation of white fat cell proliferation; bronchiole morphogenesis; limb morphogenesis; blood vessel morphogenesis; lung development; thymus development; positive regulation of fibroblast proliferation; negative regulation of cell differentiation; ERK1 and ERK2 cascade; positive regulation of epithelial cell migration; positive regulation of mitotic cell cycle; spleen development; smooth muscle cell differentiation; positive regulation of transcription, DNA-templated; positive regulation of Wnt signaling pathway; Harderian gland development; protein localization to cell surface; respiratory system development; epidermis development; positive regulation of peptidyl-tyrosine phosphorylation; metanephros morphogenesis; pancreas development; mammary gland bud formation; positive chemotaxis; mesenchymal-epithelial cell signaling involved in lung development; positive regulation of hair follicle cell proliferation; lacrimal gland development; positive regulation of MAPK cascade; cell differentiation; positive regulation of keratinocyte proliferation; positive regulation of ATP-dependent activity; positive regulation of epithelial cell proliferation involved in wound healing; epithelial cell differentiation; organ induction; positive regulation of epithelial cell proliferation; epidermis morphogenesis; wound healing; epithelial cell proliferation; regulation of activin receptor signaling pathway; positive regulation of DNA replication; chemotaxis; embryonic genitalia morphogenesis; salivary gland development; positive regulation of keratinocyte migration; response to lipopolysaccharide; thyroid gland development; keratinocyte proliferation; semicircular canal fusion; mammary gland specification; epithelial cell migration; white fat cell differentiation; regulation of gene expression; lung alveolus development; branching morphogenesis of an epithelial tube; embryonic digestive tract development; lung proximal/distal axis specification; fibroblast growth factor receptor signaling pathway involved in mammary gland specification; actin cytoskeleton reorganization; positive regulation of vascular endothelial growth factor receptor signaling pathway; pituitary gland development; response to estradiol; secretion by lung epithelial cell involved in lung growth; mesenchymal cell differentiation involved in lung development; lung morphogenesis; response to organic cyclic compound; somatic stem cell population maintenance; tissue regeneration; otic vesicle formation; epithelial cell proliferation involved in salivary gland morphogenesis; cell-cell signaling; male genitalia morphogenesis; positive regulation of DNA repair; salivary gland morphogenesis; MAPK cascade; embryonic camera-type eye development; induction of positive chemotaxis; urothelial cell proliferation; animal organ formation; fibroblast growth factor receptor signaling pathway; regulation of smoothened signaling pathway; determination of left/right symmetry; inner ear morphogenesis; positive regulation of cell population proliferation; submandibular salivary gland formation; type II pneumocyte differentiation; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; digestive tract development; regulation of epithelial cell proliferation; epithelial tube branching involved in lung morphogenesis; positive regulation of lymphocyte proliferation; positive regulation of transcription by RNA polymerase II; phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-3-phosphate biosynthetic process; peptidyl-tyrosine phosphorylation; regulation of signaling receptor activity; positive regulation of protein kinase B signaling; positive regulation of G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	2255
	14165
	ENSG00000070193
	ENSMUSG00000021732
	O15520
	O35565
	NM_004465
	NM_008002
	NP_004456
	NP_032028
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor 10 is a protein that in humans is encoded by the FGF10 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000070193 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021732 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Emoto H, Tagashira S, Mattei MG, Yamasaki M, Hashimoto G, Katsumata T, Negoro T, Nakatsuka M, Birnbaum D, Coulier F, Itoh N (September 1997). "Structure and expression of human fibroblast growth factor-10". The Journal of Biological Chemistry. 272 (37): 23191–4. doi:10.1074/jbc.272.37.23191. PMID 9287324.
^ "Entrez Gene: FGF10 fibroblast growth factor 10".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000070193 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021732 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9287324-5] Emoto H, Tagashira S, Mattei MG, Yamasaki M, Hashimoto G, Katsumata T, Negoro T, Nakatsuka M, Birnbaum D, Coulier F, Itoh N (September 1997). "Structure and expression of human fibroblast growth factor-10". The Journal of Biological Chemistry. 272 (37): 23191–4. doi:10.1074/jbc.272.37.23191. PMID 9287324.

[entrez-6] "Entrez Gene: FGF10 fibroblast growth factor 10".

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