FGF5

FGF5
Identifiers
Aliases	FGF5, HBGF-5, Smag-82, TCMGLY, fibroblast growth factor 5
External IDs	OMIM: 165190; MGI: 95519; HomoloGene: 3283; GeneCards: FGF5; OMA:FGF5 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.21 Start 80,266,639 bp[1] End 80,336,680 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 E3|5 47.77 cM Start 98,402,043 bp[2] End 98,424,889 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell stromal cell of endometrium testicle cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum gallbladder gastric mucosa skin of thigh internal globus pallidus Top expressed in embryo myotome epiblast hair follicle embryo auditory system spiral ganglion primitive endoderm endoderm larynx More reference expression data BioGPS n/a
Gene ontology Molecular function fibroblast growth factor receptor binding growth factor activity protein tyrosine kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1-phosphatidylinositol-3-kinase activity Cellular component extracellular region intracellular anatomical structure extracellular space Biological process cell-cell signaling signal transduction involved in regulation of gene expression glial cell differentiation nervous system development MAPK cascade fibroblast growth factor receptor signaling pathway positive regulation of cell population proliferation cell population proliferation positive regulation of cell division phosphatidylinositol phosphate biosynthetic process peptidyl-tyrosine phosphorylation phosphatidylinositol-3-phosphate biosynthetic process regulation of signaling receptor activity positive regulation of protein kinase B signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2250 14176 Ensembl ENSG00000138675 ENSMUSG00000029337 UniProt P12034 P15656 RefSeq (mRNA) NM_033143 NM_001291812 NM_004464 NM_001277268 NM_010203 RefSeq (protein) NP_001278741 NP_004455 NP_149134 NP_001264197 NP_034333 Location (UCSC) Chr 4: 80.27 – 80.34 Mb Chr 5: 98.4 – 98.42 Mb PubMed search [3] [4]
Wikidata
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Fibroblast growth factor 5 is a protein that in humans is encoded by the FGF5 gene.

The majority of FGF family members are glycosaminoglycan binding proteins which possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF proteins interact with a family of specific tyrosine kinase receptors, a process often regulated by proteoglycans or extracellular binding protein cofactors. A number of intracellular signalling cascades are known to be activated after FGF-FGFR interaction including PI3K-AKT, PLCγ, RAS-MAPK and STAT pathways.^[5]