FGF9

FGF9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1G82, 1IHK
Identifiers
Aliases	FGF9, FGF-9, GAF, HBFG-9, HBGF-9, SYNS3, fibroblast growth factor 9
External IDs	OMIM: 600921; MGI: 104723; HomoloGene: 1523; GeneCards: FGF9; OMA:FGF9 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	21,704,498 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	58,350,177 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; renal medulla; ; Brodmann area 23; ; pons; ; buccal mucosa cell; ; cerebellar vermis; ; middle temporal gyrus; ; parietal pleura; ; germinal epithelium; ; paraflocculus of cerebellum;
	Top expressed in
	vestibular membrane of cochlear duct; ; deep cerebellar nuclei; ; internal carotid artery; ; facial motor nucleus; ; pontine nuclei; ; muscle layer of urethra; ; substantia nigra; ; medial vestibular nucleus; ; lateral geniculate nucleus; ; cerebellar vermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	heparin binding; fibroblast growth factor receptor binding; protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase activity; growth factor activity;
Cellular component	cytoplasm; extracellular region; basement membrane; extracellular exosome; extracellular space;
Biological process	eye development; positive regulation of vascular endothelial growth factor receptor signaling pathway; cell differentiation; male gonad development; chondrocyte differentiation; substantia nigra development; protein import into nucleus; positive regulation of smoothened signaling pathway; regulation of timing of cell differentiation; positive regulation of epithelial cell proliferation; lung development; positive regulation of canonical Wnt signaling pathway; negative regulation of Wnt signaling pathway; negative regulation of transcription by RNA polymerase II; male sex determination; MAPK cascade; embryonic skeletal system development; multicellular organism development; positive regulation of gene expression; positive regulation of activin receptor signaling pathway; positive regulation of cardiac muscle cell proliferation; positive regulation of mesenchymal cell proliferation; embryonic limb morphogenesis; inner ear morphogenesis; angiogenesis; osteoblast differentiation; positive regulation of cell population proliferation; lung-associated mesenchyme development; embryonic digestive tract development; positive regulation of cell division; signal transduction; positive regulation of MAPK cascade; phosphatidylinositol phosphate biosynthetic process; fibroblast growth factor receptor signaling pathway; cell-cell signaling; phosphatidylinositol-3-phosphate biosynthetic process; peptidyl-tyrosine phosphorylation; regulation of signaling receptor activity; positive regulation of protein kinase B signaling; regulation of molecular function; positive regulation of vascular associated smooth muscle cell proliferation; positive regulation of vascular associated smooth muscle cell migration; negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching;
	Sources:Amigo / QuickGO
Orthologs
	2254
	14180
	ENSG00000102678
	ENSMUSG00000021974
	P31371
	P54130
	NM_002010
	NM_013518
	NP_002001
	NP_038546
	Wikidata
View/Edit Human	View/Edit Mouse

Glia-activating factor is a protein that in humans is encoded by the FGF9 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000102678 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021974 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Miyamoto M, Naruo K, Seko C, Matsumoto S, Kondo T, Kurokawa T (July 1993). "Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property". Molecular and Cellular Biology. 13 (7): 4251–9. doi:10.1128/mcb.13.7.4251. PMC 359975. PMID 8321227.
^ "Entrez Gene: FGF9 fibroblast growth factor 9 (glia-activating factor)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000102678 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021974 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8321227-5] Miyamoto M, Naruo K, Seko C, Matsumoto S, Kondo T, Kurokawa T (July 1993). "Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property". Molecular and Cellular Biology. 13 (7): 4251–9. doi:10.1128/mcb.13.7.4251. PMC 359975. PMID 8321227.

[entrez-6] "Entrez Gene: FGF9 fibroblast growth factor 9 (glia-activating factor)".

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