FLI1

FLI1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FLI, 1X66, 2YTU, 5E8G, 5E8I
Identifiers
Aliases	FLI1, EWSR2, SIC-1, Fli-1 proto-oncogene, ETS transcription factor, BDPLT21, FLI-1
External IDs	OMIM: 193067; MGI: 95554; HomoloGene: 55624; GeneCards: FLI1; OMA:FLI1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	128,813,267 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	32,454,157 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; spleen; ; bone marrow cells; ; trabecular bone; ; appendix; ; lymph node; ; right lung; ; upper lobe of left lung;
	Top expressed in
	dermis; ; tibiofemoral joint; ; spleen; ; left lung lobe; ; mesenteric lymph nodes; ; granulocyte; ; blood; ; genital tubercle; ; abdominal wall; ; stroma of bone marrow;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; chromatin binding; sequence-specific DNA binding; DNA-binding transcription factor activity; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; cytosol; nuclear body;
Biological process	megakaryocyte development; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; hemostasis; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; cell differentiation; animal organ morphogenesis; blood circulation; transcription, DNA-templated; positive regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	2313
	14247
	ENSG00000151702
	ENSMUSG00000016087
	Q01543
	P26323
	NM_001167681; NM_001271010; NM_001271012; NM_002017
	NM_008026
	NP_001161153; NP_001257939; NP_001257941; NP_002008; NP_001161153.1
	NP_032052
	Wikidata
View/Edit Human	View/Edit Mouse

Friend leukemia integration 1 transcription factor (FLI1), also known as transcription factor ERGB, is a protein that in humans is encoded by the FLI1 gene, which is a proto-oncogene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151702 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000016087 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Baud V, Lipinski M, Rassart E, Poliquin L, Bergeron D (September 1991). "The human homolog of the mouse common viral integration region, FLI1, maps to 11q23-q24". Genomics. 11 (1): 223–4. doi:10.1016/0888-7543(91)90124-W. PMID 1765382.
^ Prasad DD, Rao VN, Reddy ES (October 1992). "Structure and expression of human Fli-1 gene". Cancer Research. 52 (20): 5833–7. PMID 1394211.
^ Rao VN, Ohno T, Prasad DD, Bhattacharya G, Reddy ES (August 1993). "Analysis of the DNA-binding and transcriptional activation functions of human Fli-1 protein". Oncogene. 8 (8): 2167–73. PMID 8336942.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000151702 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000016087 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1765382-5] Baud V, Lipinski M, Rassart E, Poliquin L, Bergeron D (September 1991). "The human homolog of the mouse common viral integration region, FLI1, maps to 11q23-q24". Genomics. 11 (1): 223–4. doi:10.1016/0888-7543(91)90124-W. PMID 1765382.

[pmid1394211-6] Prasad DD, Rao VN, Reddy ES (October 1992). "Structure and expression of human Fli-1 gene". Cancer Research. 52 (20): 5833–7. PMID 1394211.

[pmid8336942-7] Rao VN, Ohno T, Prasad DD, Bhattacharya G, Reddy ES (August 1993). "Analysis of the DNA-binding and transcriptional activation functions of human Fli-1 protein". Oncogene. 8 (8): 2167–73. PMID 8336942.

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