FOXM1

FOXM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3G73
Identifiers
Aliases	FOXM1, FKHL16, FOXM1B, HFH-11, HFH11, HNF-3, INS-1, MPHOSPH2, MPP-2, MPP2, PIG29, TGT3, TRIDENT, forkhead box M1, FOXM1A, FOXM1C
External IDs	OMIM: 602341; MGI: 1347487; HomoloGene: 7318; GeneCards: FOXM1; OMA:FOXM1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.33 Start 2,857,680 bp[1] End 2,877,174 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F3|6 62.98 cM Start 128,339,930 bp[2] End 128,353,109 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence gonad sperm mucosa of transverse colon left testis stromal cell of endometrium right testis testicle rectum Top expressed in genital tubercle tail of embryo ventricular zone secondary oocyte zygote otic vesicle primary oocyte otic placode yolk sac seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription factor activity protein binding protein kinase binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm Biological process positive regulation of double-strand break repair regulation of Ras protein signal transduction negative regulation of transcription by RNA polymerase II regulation of reactive oxygen species metabolic process transcription by RNA polymerase II transcription, DNA-templated regulation of cell cycle cellular response to DNA damage stimulus regulation of cell population proliferation G2/M transition of mitotic cell cycle regulation of cell growth positive regulation of cell population proliferation negative regulation of stress-activated MAPK cascade negative regulation of transcription, DNA-templated DNA repair positive regulation of transcription by RNA polymerase II DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator regulation of transcription, DNA-templated anatomical structure morphogenesis cell differentiation cell cycle positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2305 14235 Ensembl ENSG00000111206 ENSMUSG00000001517 UniProt Q08050 O08696 RefSeq (mRNA) NM_001243088 NM_001243089 NM_021953 NM_202002 NM_202003 NM_008021 RefSeq (protein) NP_001230017 NP_001230018 NP_068772 NP_973731 NP_973732 n/a Location (UCSC) Chr 12: 2.86 – 2.88 Mb Chr 6: 128.34 – 128.35 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Forkhead box protein M1 is a protein that in humans is encoded by the FOXM1 gene.^[5][6] The protein encoded by this gene is a member of the FOX family of transcription factors.^[5][7] Its potential as a target for future cancer treatments led to it being designated the 2010 Molecule of the Year.^[8]