FOXO4

FOXO4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1E17, 3L2C
Identifiers
Aliases	FOXO4, AFX, AFX1, MLLT7, forkhead box O4
External IDs	OMIM: 300033; MGI: 1891915; HomoloGene: 4342; GeneCards: FOXO4; OMA:FOXO4 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	71,103,532 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	100,304,479 bp
RNA expression pattern
	Top expressed in
	beta cell; ; olfactory bulb; ; gastrocnemius muscle; ; C1 segment; ; amygdala; ; muscle of thigh; ; internal globus pallidus; ; putamen; ; thoracic diaphragm; ; external globus pallidus;
	Top expressed in
	muscle of thigh; ; yolk sac; ; blood; ; decidua; ; gastrula; ; triceps brachii muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; ankle; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; enzyme binding; transcription factor binding; beta-catenin binding; identical protein binding; DNA binding; DNA-binding transcription factor activity; promoter-specific chromatin binding; DNA-binding transcription activator activity, RNA polymerase II-specific; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; cytosol; nucleus; nucleoplasm; nuclear speck;
Biological process	positive regulation of transcription, DNA-templated; negative regulation of smooth muscle cell differentiation; negative regulation of G0 to G1 transition; insulin receptor signaling pathway; negative regulation of angiogenesis; multicellular organism development; cell differentiation; transcription, DNA-templated; muscle organ development; stem cell differentiation; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; mitotic G2 DNA damage checkpoint signaling; cell cycle; regulation of transcription, DNA-templated; negative regulation of cell population proliferation; response to water-immersion restraint stress; response to nutrient levels; human ageing; positive regulation of smooth muscle cell migration; protein deubiquitination; negative regulation of transcription by RNA polymerase II; glucose homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	4303
	54601
	ENSG00000184481
	ENSMUSG00000042903
	P98177
	Q9WVH3
	NM_001170931; NM_005938
	NM_018789
	NP_001164402; NP_005929
	NP_061259
	Wikidata
View/Edit Human	View/Edit Mouse

Forkhead box protein O4 is a protein that in humans is encoded by the FOXO4 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184481 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042903 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Parry P, Wei Y, Evans G (Feb 1995). "Cloning and characterization of the t(X;11) breakpoint from a leukemic cell line identify a new member of the forkhead gene family". Genes Chromosomes Cancer. 11 (2): 79–84. doi:10.1002/gcc.2870110203. PMID 7529552. S2CID 19965473.
^ "FOXO4 forkhead box O4 [ Homo sapiens (human) ]".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184481 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042903 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7529552-5] Parry P, Wei Y, Evans G (Feb 1995). "Cloning and characterization of the t(X;11) breakpoint from a leukemic cell line identify a new member of the forkhead gene family". Genes Chromosomes Cancer. 11 (2): 79–84. doi:10.1002/gcc.2870110203. PMID 7529552. S2CID 19965473.

[entrez-6] "FOXO4 forkhead box O4 [ Homo sapiens (human) ]".

[1]

[2]

[3]

[4]

[5]

[6]