FOXP1

FOXP1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2KIU
Identifiers
Aliases	FOXP1, 12CC4, HSPC215, MFH, QRF1, hFKH1B, forkhead box P1
External IDs	OMIM: 605515; HomoloGene: 136512; GeneCards: FOXP1; OMA:FOXP1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p13 Start 70,954,693 bp[1] End 71,583,978 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell cardia saphenous vein pylorus mucosa of ileum pericardium urethra buccal mucosa cell epithelium of lactiferous gland lactiferous duct n/a More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding sequence-specific DNA binding protein self-association androgen receptor binding DNA-binding transcription factor activity DNA binding protein binding identical protein binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding chromatin binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription factor binding protein homodimerization activity protein heterodimerization activity Cellular component nucleus nucleoplasm cytoplasm Biological process regulation of monocyte differentiation negative regulation of androgen receptor signaling pathway negative regulation of B cell apoptotic process positive regulation of endothelial cell migration transcription, DNA-templated response to lipopolysaccharide regulation of defense response to bacterium endothelial cell activation regulation of endothelial tube morphogenesis macrophage activation osteoclast development positive regulation of smooth muscle cell proliferation T follicular helper cell differentiation regulation of macrophage colony-stimulating factor production regulation of tumor necrosis factor production regulation of inflammatory response osteoclast differentiation monocyte activation regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II somatic stem cell population maintenance negative regulation of transcription by RNA polymerase II in utero embryonic development positive regulation of mesenchymal cell proliferation pre-B cell differentiation positive regulation of immunoglobulin production heart development skeletal muscle tissue development motor neuron axon guidance ventral spinal cord development striatum development lung development forebrain development immunoglobulin V(D)J recombination response to testosterone sarcomere organization positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II smooth muscle tissue development positive regulation of epithelial cell proliferation cardiac muscle cell differentiation regulation of cardiac muscle cell proliferation negative regulation of cell growth involved in cardiac muscle cell development lung secretory cell differentiation cellular response to tumor necrosis factor innate vocalization behavior regulation of action potential regulation of lung goblet cell differentiation negative regulation of lung goblet cell differentiation cellular response to ionomycin positive regulation of hydrogen peroxide-induced cell death positive regulation of cardiac muscle cell differentiation cellular response to DNA damage stimulus negative regulation of gene expression positive regulation of B cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27086 n/a Ensembl ENSG00000114861 n/a UniProt Q9H334 n/a RefSeq (mRNA) NM_001012505 NM_001244808 NM_001244810 NM_001244812 NM_001244813 NM_001244814 NM_001244815 NM_001244816 NM_032682 NM_001349338 NM_001349340 NM_001349341 NM_001349342 NM_001349343 NM_001349344 NM_001349337 NM_001370548 n/a RefSeq (protein) NP_001012523 NP_001231737 NP_001231739 NP_001231741 NP_001231742 NP_001231743 NP_001231744 NP_001231745 NP_116071 NP_001336267 NP_001336269 NP_001336270 NP_001336271 NP_001336272 NP_001336273 NP_001336266 n/a Location (UCSC) Chr 3: 70.95 – 71.58 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Forkhead box protein P1 is a protein that in humans is encoded by the FOXP1 gene. FOXP1 is necessary for the proper development of the brain, heart, and lung in mammals. It is a member of the large FOX family of transcription factors.