FRAS1

FRAS1
Identifiers
Aliases	FRAS1, Fraser extracellular matrix complex subunit 1, FRASRS1
External IDs	OMIM: 607830; MGI: 2385368; HomoloGene: 23516; GeneCards: FRAS1; OMA:FRAS1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	78,544,269 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	96,932,587 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; parietal pleura; ; renal medulla; ; Brodmann area 23; ; visceral pleura; ; middle temporal gyrus; ; lateral nuclear group of thalamus; ; epithelium of colon; ; placenta; ; biceps brachii;
	Top expressed in
	fourth ventricle; ; choroid plexus of fourth ventricle; ; molar; ; squamous epithelium; ; hand; ; choroidal fissure; ; mesothelium; ; pericardium; ; atrium; ; mesothelium of peritoneum;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; extracellular matrix structural constituent;
Cellular component	plasma membrane; extracellular matrix; membrane; basement membrane; integral component of membrane; collagen-containing extracellular matrix;
Biological process	skin development; embryonic limb morphogenesis; protein transport; metanephros morphogenesis; morphogenesis of an epithelium; roof of mouth development; cell communication;
	Sources:Amigo / QuickGO
Orthologs
	80144
	231470
	ENSG00000138759
	ENSMUSG00000034687
	Q86XX4
	Q80T14
	NM_001166133; NM_020875; NM_025074; NM_032863; NM_206841
	NM_175473
	NP_001159605; NP_079350
	NP_780682
	Wikidata
View/Edit Human	View/Edit Mouse

Extracellular matrix protein FRAS1 is a protein that in humans is encoded by the FRAS1 (Fraser syndrome 1) gene.^[5]^[6] This gene encodes an extracellular matrix protein that appears to function in the regulation of epidermal-basement membrane adhesion and organogenesis during development.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138759 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034687 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Fraser syndrome 1".
^ McGregor L, Makela V, Darling SM, Vrontou S, Chalepakis G, Roberts C, et al. (June 2003). "Fraser syndrome and mouse blebbed phenotype caused by mutations in FRAS1/Fras1 encoding a putative extracellular matrix protein". Nature Genetics. 34 (2): 203–208. doi:10.1038/ng1142. PMID 12766769. S2CID 1018128.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138759 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034687 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Fraser syndrome 1".

[pmid12766769-6] McGregor L, Makela V, Darling SM, Vrontou S, Chalepakis G, Roberts C, et al. (June 2003). "Fraser syndrome and mouse blebbed phenotype caused by mutations in FRAS1/Fras1 encoding a putative extracellular matrix protein". Nature Genetics. 34 (2): 203–208. doi:10.1038/ng1142. PMID 12766769. S2CID 1018128.

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