FSCN1

FSCN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DFC, 4GP0, 4GP3, 3P53, 4GOY, 4GOV, 3LLP
Identifiers
Aliases	FSCN1, FAN1, HSN, SNL, p55, fascin actin-bundling protein 1
External IDs	OMIM: 602689; MGI: 1352745; HomoloGene: 48164; GeneCards: FSCN1; OMA:FSCN1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	5,606,655 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	142,958,940 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; ganglionic eminence; ; middle frontal gyrus; ; frontal pole; ; Brodmann area 10; ; C1 segment; ; ventricular zone; ; right frontal lobe; ; putamen; ; amygdala;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; abdominal wall; ; Rostral migratory stream; ; endothelial cell of lymphatic vessel; ; condyle; ; primitive streak; ; endocardial cushion; ; fossa; ; mandibular prominence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; actin filament binding; protein binding; actin binding; RNA binding; cadherin binding;
Cellular component	cytoplasm; cell projection; cell-cell junction; filopodium; ruffle; myelin sheath; stress fiber; microvillus; cell junction; microspike; cell projection membrane; actin cytoskeleton; podosome; extracellular exosome; cytoskeleton; growth cone; lamellipodium; filamentous actin; cytosol;
Biological process	regulation of microvillus assembly; establishment of apical/basal cell polarity; regulation of actin cytoskeleton organization; actin filament organization; cell motility; positive regulation of podosome assembly; actin filament bundle assembly; positive regulation of extracellular matrix disassembly; cell-cell junction assembly; microspike assembly; cell population proliferation; positive regulation of lamellipodium assembly; cell migration; positive regulation of filopodium assembly; actin cytoskeleton organization; anatomical structure morphogenesis; establishment or maintenance of cell polarity; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6624
	14086
	ENSG00000075618
	ENSMUSG00000029581
	Q16658
	Q61553
	NM_003088
	NM_007984
	NP_003079
	NP_032010
	Wikidata
View/Edit Human	View/Edit Mouse

Fascin is a protein that in humans is encoded by the FSCN1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000075618 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029581 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Duh FM, Latif F, Weng Y, Geil L, Modi W, Stackhouse T, Matsumura F, Duan DR, Linehan WM, Lerman MI (Sep 1994). "cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein". DNA Cell Biol. 13 (8): 821–7. doi:10.1089/dna.1994.13.821. PMID 8068206.
^ Tubb BE, Bardien-Kruger S, Kashork CD, Shaffer LG, Ramagli LS, Xu J, Siciliano MJ, Bryan J (Jul 2000). "Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes". Genomics. 65 (2): 146–56. doi:10.1006/geno.2000.6156. PMID 10783262.
^ "Entrez Gene: FSCN1 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000075618 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029581 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8068206-5] Duh FM, Latif F, Weng Y, Geil L, Modi W, Stackhouse T, Matsumura F, Duan DR, Linehan WM, Lerman MI (Sep 1994). "cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein". DNA Cell Biol. 13 (8): 821–7. doi:10.1089/dna.1994.13.821. PMID 8068206.

[pmid10783262-6] Tubb BE, Bardien-Kruger S, Kashork CD, Shaffer LG, Ramagli LS, Xu J, Siciliano MJ, Bryan J (Jul 2000). "Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes". Genomics. 65 (2): 146–56. doi:10.1006/geno.2000.6156. PMID 10783262.

[entrez-7] "Entrez Gene: FSCN1 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)".

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