FSHB

FSHB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FL7, 1XWD, 4AY9, 4MQW
Identifiers
Aliases	FSHB, HH24, follicle stimulating hormone beta subunit, Follitropin subunit beta, follicle stimulating hormone subunit beta
External IDs	OMIM: 136530; MGI: 95582; HomoloGene: 430; GeneCards: FSHB; OMA:FSHB - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	30,235,261 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	106,890,001 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; testicle; ; amygdala; ; mammary gland; ; breast; ; lactiferous gland; ; right lung; ; connective tissue; ; adipose tissue; ; ventricle;
	Top expressed in
	pituitary gland; ; anterior pituitary; ; pars distalis of adenohypophysis; ; secondary oocyte; ; median eminence; ; nucleus of stria terminalis; ; vasculature of organ; ; hypothalamus; ; hippocampal formation; ; hippocampus proper;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	follicle-stimulating hormone activity; protein binding; hormone activity;
Cellular component	cytoplasm; extracellular region; extracellular space; follicle-stimulating hormone complex;
Biological process	progesterone biosynthetic process; female gamete generation; positive regulation of bone resorption; regulation of osteoclast differentiation; transforming growth factor beta receptor signaling pathway; positive regulation of cell migration; positive regulation of transcription by RNA polymerase II; female pregnancy; positive regulation of cell population proliferation; ovarian follicle development; Sertoli cell proliferation; signal transduction; peptide hormone processing; positive regulation of gene expression; cell-cell signaling; hormone-mediated signaling pathway; follicle-stimulating hormone signaling pathway; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; positive regulation of steroid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	2488
	14308
	ENSG00000131808
	ENSMUSG00000027120
	P01225
	Q60687
	NM_000510; NM_001018080; NM_001382289
	NM_008045
	NP_000501; NP_001018090; NP_001369218
	NP_032071
	Wikidata
View/Edit Human	View/Edit Mouse

Follitropin subunit beta also known as follicle-stimulating hormone beta subunit (FSH-B) is a protein that in humans is encoded by the FSHB gene.^[5]^[6]^[7] Alternative splicing results in two transcript variants encoding the same protein.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000131808 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027120 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Watkins PC, Eddy R, Beck AK, Vellucci V, Leverone B, Tanzi RE, Gusella JF, Shows TB (Aug 1987). "DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11". DNA. 6 (3): 205–12. doi:10.1089/dna.1987.6.205. PMID 2885163.
^ Shome B, Parlow AF, Liu WK, Nahm HS, Wen T, Ward DN (Sep 1989). "A reevaluation of the amino acid sequence of human follitropin beta-subunit". J Protein Chem. 7 (4): 325–39. doi:10.1007/BF01024882. PMID 3151250. S2CID 20497546.
^ "Entrez Gene: FSHB follicle stimulating hormone, beta polypeptide".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000131808 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027120 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2885163-5] Watkins PC, Eddy R, Beck AK, Vellucci V, Leverone B, Tanzi RE, Gusella JF, Shows TB (Aug 1987). "DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11". DNA. 6 (3): 205–12. doi:10.1089/dna.1987.6.205. PMID 2885163.

[pmid3151250-6] Shome B, Parlow AF, Liu WK, Nahm HS, Wen T, Ward DN (Sep 1989). "A reevaluation of the amino acid sequence of human follitropin beta-subunit". J Protein Chem. 7 (4): 325–39. doi:10.1007/BF01024882. PMID 3151250. S2CID 20497546.

[entrez-7] "Entrez Gene: FSHB follicle stimulating hormone, beta polypeptide".

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