Fas ligand

FASLG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4MSV
Identifiers
Aliases	FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6, TNLG1A, Fas ligand
External IDs	OMIM: 134638; MGI: 99255; HomoloGene: 533; GeneCards: FASLG; OMA:FASLG - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q24.3 Start 172,659,103 bp[1] End 172,666,876 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H2.1|1 69.95 cM Start 161,608,258 bp[2] End 161,616,064 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood lymph node spleen jejunal mucosa mucosa of ileum gallbladder duodenum rectum bone marrow Top expressed in blastocyst lumbar subsegment of spinal cord embryo blood embryo spermatid placenta spleen decidua duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity protein binding tumor necrosis factor receptor binding signaling receptor binding death receptor binding Cellular component integral component of membrane membrane cytoplasmic vesicle lumen plasma membrane integral component of plasma membrane cell surface lysosomal lumen caveola perinuclear region of cytoplasm membrane raft lysosome extracellular exosome cytoplasmic vesicle nucleus external side of plasma membrane extracellular region extracellular space Biological process T cell apoptotic process regulation of transcription, DNA-templated cell-cell signaling endosomal lumen acidification negative regulation of transcription by RNA polymerase II retinal cell programmed cell death transcription, DNA-templated response to lipopolysaccharide positive regulation of neuron apoptotic process positive regulation of endothelial cell apoptotic process necroptotic signaling pathway immune response positive regulation of cell population proliferation positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of angiogenesis regulation of extrinsic apoptotic signaling pathway via death domain receptors cellular chloride ion homeostasis response to growth factor inflammatory cell apoptotic process positive regulation of epidermal growth factor receptor signaling pathway extrinsic apoptotic signaling pathway via death domain receptors signal transduction extrinsic apoptotic signaling pathway activation of cysteine-type endopeptidase activity involved in apoptotic process necroptosis apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway via death domain receptors apoptotic process release of sequestered calcium ion into cytosol by endoplasmic reticulum regulation of signaling receptor activity cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 356 14103 Ensembl ENSG00000117560 ENSMUSG00000000817 UniProt P48023 P41047 RefSeq (mRNA) NM_001302746 NM_000639 NM_001205243 NM_010177 RefSeq (protein) NP_000630 NP_001289675 NP_001192172 NP_034307 Location (UCSC) Chr 1: 172.66 – 172.67 Mb Chr 1: 161.61 – 161.62 Mb PubMed search [3] [4]
Wikidata
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Fas ligand (FASL or CD95L) is a type-II transmembrane protein expressed on various types of cells, including cytotoxic T lymphocytes, monocytes, neutrophils, breast epithelial cells, vascular endothelial cells and natural killer (NK) cells. It binds with its receptor, called FAS receptor (also called CD95) and plays a crucial role in the regulation of the immune system and in induction of apoptosis, a programmed cell death.^[5]