Felbamate

Felbamate
Clinical data
Trade namesFelbatol
AHFS/Drugs.comMonograph
MedlinePlusa606011
Routes of
administration
By mouth (tablets, oral suspension)
ATC code
Legal status
Legal status
  • US: WARNING[1]
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability>90%
MetabolismHepatic
Elimination half-life20–23 hours
Identifiers
  • (3-carbamoyloxy-2-phenylpropyl) carbamate
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.042.714 Edit this at Wikidata
Chemical and physical data
FormulaC11H14N2O4
Molar mass238.243 g·mol−1
3D model (JSmol)
  • O=C(N)OCC(c1ccccc1)COC(N)=O
  • InChI=1S/C11H14N2O4/c12-10(14)16-6-9(7-17-11(13)15)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H2,12,14)(H2,13,15) checkY
  • Key:WKGXYQFOCVYPAC-UHFFFAOYSA-N checkY
  (verify)

Felbamate (marketed under the brand name Felbatol by MedPointe) is an anticonvulsant[2] used in the treatment of epilepsy. It is used to treat partial seizures[3][4] (with and without generalization) in adults and partial and generalized seizures associated with Lennox–Gastaut syndrome in children. However, an increased risk of potentially fatal aplastic anemia and/or liver failure limit the drug's usage to severe refractory epilepsy.

  1. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
  2. ^ Rho JM, Donevan SD, Rogawski MA (March 1997). "Barbiturate-Like Actions of the Propanediol Dicarbamates Felbamate and Meprobamate". J. Pharmacol. Exp. Ther. 280 (3): 1383–91. PMID 9067327.
  3. ^ Leppik IE, Dreifuss FE, Pledger GW, et al. (November 1991). "Felbamate for Partial Seizures: Results of a Controlled Clinical Trial". Neurology. 41 (11): 1785–9. doi:10.1212/wnl.41.11.1785. PMID 1944909. S2CID 25245002.
  4. ^ Devinsky O, Faught RE, Wilder BJ, et al. (March 1995). "Efficacy of Felbamate Monotherapy in Patients Undergoing Presurgical Evaluation of Partial Seizures". Epilepsy Res. 20 (3): 241–6. doi:10.1016/0920-1211(94)00084-A. PMID 7796796. S2CID 21915205.