Felbamate

Felbamate
Clinical data
Trade names	Felbatol
AHFS/Drugs.com	Monograph
MedlinePlus	a606011
Routes of; administration	By mouth (tablets, oral suspension)
ATC code	N03AX10 (WHO) ;
Legal status
Legal status	US: WARNING; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	>90%
Metabolism	Hepatic
Elimination half-life	20–23 hours
Identifiers
	IUPAC name (3-carbamoyloxy-2-phenylpropyl) carbamate;
CAS Number	25451-15-4 ;
PubChem CID	3331;
IUPHAR/BPS	5473;
DrugBank	DB00949 ;
ChemSpider	3214 ;
UNII	X72RBB02N8;
KEGG	D00536 ;
ChEBI	CHEBI:4995 ;
ChEMBL	ChEMBL1094 ;
CompTox Dashboard (EPA)	DTXSID9023041 ;
ECHA InfoCard	100.042.714
Chemical and physical data
Formula	C11H14N2O4
Molar mass	238.243 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(N)OCC(c1ccccc1)COC(N)=O;
	InChI InChI=1S/C11H14N2O4/c12-10(14)16-6-9(7-17-11(13)15)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H2,12,14)(H2,13,15) ; Key:WKGXYQFOCVYPAC-UHFFFAOYSA-N ;
	(verify)

Felbamate (marketed under the brand name Felbatol by MedPointe) is an anticonvulsant^[2] used in the treatment of epilepsy. It is used to treat partial seizures^[3]^[4] (with and without generalization) in adults and partial and generalized seizures associated with Lennox–Gastaut syndrome in children. However, an increased risk of potentially fatal aplastic anemia and/or liver failure limit the drug's usage to severe refractory epilepsy.

^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^ Rho JM, Donevan SD, Rogawski MA (March 1997). "Barbiturate-Like Actions of the Propanediol Dicarbamates Felbamate and Meprobamate". J. Pharmacol. Exp. Ther. 280 (3): 1383–91. PMID 9067327.
^ Leppik IE, Dreifuss FE, Pledger GW, et al. (November 1991). "Felbamate for Partial Seizures: Results of a Controlled Clinical Trial". Neurology. 41 (11): 1785–9. doi:10.1212/wnl.41.11.1785. PMID 1944909. S2CID 25245002.
^ Devinsky O, Faught RE, Wilder BJ, et al. (March 1995). "Efficacy of Felbamate Monotherapy in Patients Undergoing Presurgical Evaluation of Partial Seizures". Epilepsy Res. 20 (3): 241–6. doi:10.1016/0920-1211(94)00084-A. PMID 7796796. S2CID 21915205.

[FDA-AllBoxedWarnings-1] "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.

[pmid9067327-2] Rho JM, Donevan SD, Rogawski MA (March 1997). "Barbiturate-Like Actions of the Propanediol Dicarbamates Felbamate and Meprobamate". J. Pharmacol. Exp. Ther. 280 (3): 1383–91. PMID 9067327.

[pmid1944909-3] Leppik IE, Dreifuss FE, Pledger GW, et al. (November 1991). "Felbamate for Partial Seizures: Results of a Controlled Clinical Trial". Neurology. 41 (11): 1785–9. doi:10.1212/wnl.41.11.1785. PMID 1944909. S2CID 25245002.

[pmid7796796-4] Devinsky O, Faught RE, Wilder BJ, et al. (March 1995). "Efficacy of Felbamate Monotherapy in Patients Undergoing Presurgical Evaluation of Partial Seizures". Epilepsy Res. 20 (3): 241–6. doi:10.1016/0920-1211(94)00084-A. PMID 7796796. S2CID 21915205.

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