Enrico Fermi (1901–1954) was an Italian physicist who created the world's first nuclear reactor.
Fermi or Enrico Fermi may also refer to:
- Fermi (crater), a large lunar impact crater
- Fermi (microarchitecture), a microarchitecture developed by Nvidia
- Fermi (supercomputer), located at CINECA in Italy
- Fermi (Turin Metro), a rapid transit station in Italy
- Fermi (unit), a unit of length in nuclear physics equivalent to the femtometre
- RA-1 Enrico Fermi, a research reactor in Argentina
- Fermi Gamma-ray Space Telescope
- Enrico Fermi Institute, Chicago, Illinois, US
- Fermi Linux, distributions produced by Fermilab
- FERMI, a free-electron laser at the ELETTRA research centre