Ferroportin

SLC40A1
Identifiers
Aliases	SLC40A1, IREG1, MST079, MSTP079, solute carrier family 40 member 1, MTP1, SLC11A3, FPN1, HFE4
External IDs	OMIM: 604653; MGI: 1315204; HomoloGene: 40959; GeneCards: SLC40A1; OMA:SLC40A1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q32.2 Start 189,560,590 bp[1] End 189,583,758 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C1.1 Start 45,947,228 bp[2] End 45,965,683 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell jejunal mucosa mucosa of ileum germinal epithelium trabecular bone decidua cardiac muscle tissue of right atrium palpebral conjunctiva superficial temporal artery duodenum Top expressed in epithelium of small intestine medullary collecting duct stroma of bone marrow duodenum spleen tibiofemoral joint left colon granulocyte liver ileum More reference expression data BioGPS n/a
Gene ontology Molecular function ferrous iron transmembrane transporter activity iron ion transmembrane transporter activity peptide hormone binding protein binding identical protein binding Cellular component cytoplasm integral component of membrane membrane synaptic vesicle plasma membrane integral component of plasma membrane intracellular anatomical structure basolateral plasma membrane nucleoplasm cytosol Biological process iron ion transmembrane transport lymphocyte homeostasis spleen trabecula formation iron ion homeostasis negative regulation of apoptotic process ion transport spleen development multicellular organismal iron ion homeostasis iron ion transport endothelium development iron ion export across plasma membrane positive regulation of transcription by RNA polymerase II cellular iron ion homeostasis regulation of transcription from RNA polymerase II promoter in response to iron Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 30061 53945 Ensembl ENSG00000138449 ENSMUSG00000025993 UniProt Q9NP59 Q9JHI9 RefSeq (mRNA) NM_014585 NM_016917 RefSeq (protein) NP_055400 NP_058613 Location (UCSC) Chr 2: 189.56 – 189.58 Mb Chr 1: 45.95 – 45.97 Mb PubMed search [3] [4]
Wikidata
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Ferroportin-1, also known as solute carrier family 40 member 1 (SLC40A1) or iron-regulated transporter 1 (IREG1), is a protein that in humans is encoded by the SLC40A1 gene.^[5] Ferroportin is a transmembrane protein that transports iron from the inside of a cell to the outside of the cell. Ferroportin is the only known iron exporter.^[6]

After dietary iron is absorbed into the cells of the small intestine, ferroportin allows that iron to be transported out of those cells and into the bloodstream. Fpn also mediates the efflux of iron recycled from macrophages resident in the spleen and liver.^[7]

Ferroportin is regulated by hepcidin, a hormone produced by the liver; hepcidin binds to Fpn and limits its iron-efflux activity, thereby reducing iron delivery to the blood plasma.^[8] Therefore, the interaction between Fpn and hepcidin controls systemic iron homeostasis.