Fibrinogen alpha chain

FGA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BBR, 1DM4, 1FPH, 1FZA, 1FZB, 1FZC, 1FZD, 1FZE, 1FZF, 1FZG, 1LT9, 1LTJ, 1N86, 1N8E, 1RE3, 1RE4, 1RF0, 1RF1, 1YCP, 2A45, 2FFD, 2H43, 2HLO, 2HOD, 2HPC, 2OYH, 2OYI, 2Q9I, 2XNX, 2XNY, 2Z4E, 3AT0, 3BVH, 3E1I, 3GHG, 3H32, 3HUS, 4F27, 5CFA
Identifiers
Aliases	FGA, Fib2, fibrinogen alpha chain
External IDs	OMIM: 134820; MGI: 1316726; HomoloGene: 428; GeneCards: FGA; OMA:FGA - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	154,590,745 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	82,940,934 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; islet of Langerhans; ; beta cell; ; body of stomach; ; testicle; ; fundus; ; decidua; ; cerebellar vermis; ; cardia; ; body of pancreas;
	Top expressed in
	left lobe of liver; ; gallbladder; ; human fetus; ; yolk sac; ; fetal liver hematopoietic progenitor cell; ; right kidney; ; proximal tubule; ; sexually immature organism; ; human kidney; ; epithelium of small intestine;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; structural molecule activity; metal ion binding; protein binding; signaling receptor binding; cell adhesion molecule binding;
Cellular component	platelet alpha granule; extracellular vesicle; plasma membrane; fibrinogen complex; extracellular region; cell surface; cell cortex; extracellular exosome; platelet alpha granule lumen; external side of plasma membrane; blood microparticle; extracellular space; endoplasmic reticulum lumen;
Biological process	hemostasis; negative regulation of endothelial cell apoptotic process; positive regulation of peptide hormone secretion; protein polymerization; positive regulation of heterotypic cell-cell adhesion; adaptive immune response; fibrinolysis; immune system process; platelet degranulation; blood coagulation; extracellular matrix organization; response to calcium ion; positive regulation of substrate adhesion-dependent cell spreading; blood coagulation, common pathway; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of vasoconstriction; positive regulation of protein secretion; positive regulation of ERK1 and ERK2 cascade; negative regulation of blood coagulation, common pathway; positive regulation of exocytosis; blood coagulation, fibrin clot formation; plasminogen activation; cell-matrix adhesion; innate immune response; platelet aggregation; signal transduction; induction of bacterial agglutination; platelet activation; toll-like receptor signaling pathway; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	2243
	14161
	ENSG00000171560
	ENSMUSG00000028001
	P02671
	E9PV24
	NM_000508; NM_021871
	NM_001111048; NM_010196
	NP_000499; NP_068657
	NP_001104518; NP_034326
	Wikidata
View/Edit Human	View/Edit Mouse

Fibrinogen alpha chain is a protein that in humans is encoded by the FGA gene.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171560 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028001 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171560 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028001 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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