Fibrinoid necrosis

Micrograph showing (intensely pink) fibrinoid necrosis (large blood vessel – right of image) in a case of vasculitis (eosinophilic granulomatosis with polyangiitis). H&E stain.

Fibrinoid necrosis is a specific pattern of irreversible, uncontrolled cell death that occurs when antigen-antibody complexes are deposited in the walls of blood vessels along with fibrin. It is common in the immune-mediated vasculitides which are a result of type III hypersensitivity. When stained with hematoxylin and eosin, they appear brightly eosinophilic and smudged.[1]

  1. ^ Robbins and Cotran pathologic basis of disease. Kumar, Vinay, Abbas, Abul K., Aster, Jon C., Perkins, James A. (Ninth ed.). Philadelphia, PA. 2014. ISBN 9781455726134. OCLC 879416939.{{cite book}}: CS1 maint: location missing publisher (link) CS1 maint: others (link)