Fibroblast growth factor 23

FGF23
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2P39
Identifiers
Aliases	FGF23, ADHR, FGFN, HPDR2, HYPF, PHPTC, fibroblast growth factor 23, HFTC2
External IDs	OMIM: 605380; MGI: 1891427; HomoloGene: 10771; GeneCards: FGF23; OMA:FGF23 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.32 Start 4,368,227 bp[1] End 4,379,712 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 F3 Start 127,049,865 bp[2] End 127,058,371 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve gonad testicle right auricle liver right lobe of liver muscle of thigh muscle tissue primary visual cortex blood Top expressed in embryo lumbar spinal ganglion zygote lumbar subsegment of spinal cord tibiofemoral joint superior frontal gyrus extraocular muscle vastus lateralis muscle carotid body major salivary gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function fibroblast growth factor receptor binding type 1 fibroblast growth factor receptor binding growth factor activity protein tyrosine kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1-phosphatidylinositol-3-kinase activity protein binding Cellular component extracellular region Golgi lumen endoplasmic reticulum lumen extracellular space Biological process cell differentiation negative regulation of bone mineralization cellular response to interleukin-6 vitamin D metabolic process regulation of bone mineralization phosphate ion homeostasis cellular phosphate ion homeostasis response to magnesium ion regulation of phosphate transport cellular response to vitamin D negative regulation of osteoblast differentiation cellular response to leptin stimulus positive regulation of transcription, DNA-templated fibroblast growth factor receptor signaling pathway response to sodium phosphate positive regulation of ERK1 and ERK2 cascade positive regulation of vitamin D 24-hydroxylase activity phosphate-containing compound metabolic process vitamin D catabolic process positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway cellular response to parathyroid hormone stimulus negative regulation of hormone secretion phosphatidylinositol phosphate biosynthetic process peptidyl-tyrosine phosphorylation phosphatidylinositol-3-phosphate biosynthetic process MAPK cascade post-translational protein modification regulation of signaling receptor activity positive regulation of protein kinase B signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8074 64654 Ensembl ENSG00000118972 ENSMUSG00000000182 UniProt Q9GZV9 Q9EPC2 RefSeq (mRNA) NM_020638 NM_022657 RefSeq (protein) NP_065689 NP_073148 Location (UCSC) Chr 12: 4.37 – 4.38 Mb Chr 6: 127.05 – 127.06 Mb PubMed search [3] [4]
Wikidata
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Fibroblast growth factor 23 (FGF-23) is a protein and member of the fibroblast growth factor (FGF) family which participates in the regulation of phosphate in plasma and vitamin D metabolism. In humans it is encoded by the FGF23 gene. FGF-23 decreases reabsorption of phosphate in the kidney. Mutations in FGF23 can lead to its increased activity, resulting in autosomal dominant hypophosphatemic rickets.