Fibroblast growth factor 8

FGF8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FDB
Identifiers
Aliases	FGF8, AIGF, FGF-8, HBGF-8, HH6, KAL6, fibroblast growth factor 8
External IDs	OMIM: 600483; MGI: 99604; HomoloGene: 7715; GeneCards: FGF8; OMA:FGF8 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	101,780,371 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	45,731,354 bp
RNA expression pattern
	Top expressed in
	gonad; ; sural nerve; ; Brodmann area 9; ; monocyte; ; cingulate gyrus; ; anterior cingulate cortex; ; prefrontal cortex; ; right frontal lobe; ; tendon; ; primary visual cortex;
	Top expressed in
	surface ectoderm; ; Apical ectodermal ridge; ; footplate; ; third ventricle; ; medial nasal prominence; ; pituitary stalk; ; infundibular recess; ; tail of embryo; ; lateral nasal prominence; ; endoderm;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	type 1 fibroblast growth factor receptor binding; type 2 fibroblast growth factor receptor binding; growth factor activity; fibroblast growth factor receptor binding; chemoattractant activity; protein tyrosine kinase activity; 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
Cellular component	extracellular region; intracellular anatomical structure; external side of plasma membrane; extracellular space;
Biological process	negative regulation of neuron apoptotic process; cell migration involved in mesendoderm migration; male genitalia development; epithelial to mesenchymal transition involved in endocardial cushion formation; outflow tract morphogenesis; embryonic heart tube development; mesonephros development; heart looping; forebrain neuron development; blood vessel remodeling; central nervous system neuron development; positive regulation of ERK1 and ERK2 cascade; metanephros development; cell proliferation in forebrain; positive regulation of mitotic nuclear division; gonad development; pharyngeal system development; branching involved in salivary gland morphogenesis; apoptotic process; dopaminergic neuron differentiation; cell fate commitment; limb morphogenesis; kidney development; lung development; anatomical structure morphogenesis; signal transduction involved in regulation of gene expression; regulation of odontogenesis of dentin-containing tooth; response to oxidative stress; embryo development ending in birth or egg hatching; forebrain morphogenesis; heart development; telencephalon development; branching involved in ureteric bud morphogenesis; midbrain-hindbrain boundary development; branching involved in blood vessel morphogenesis; thyroid-stimulating hormone-secreting cell differentiation; positive chemotaxis; mesodermal cell migration; cell differentiation; dorsal/ventral axon guidance; corticotropin hormone secreting cell differentiation; organ induction; neural plate morphogenesis; positive regulation of organ growth; negative regulation of apoptotic process; BMP signaling pathway; outflow tract septum morphogenesis; odontogenesis; thyroid gland development; pallium development; gastrulation; canonical Wnt signaling pathway; subpallium development; lung morphogenesis; response to organic cyclic compound; otic vesicle formation; forebrain dorsal/ventral pattern formation; heart morphogenesis; aorta morphogenesis; generation of neurons; MAPK cascade; neuroepithelial cell differentiation; multicellular organism development; fibroblast growth factor receptor signaling pathway; positive regulation of gene expression; negative regulation of cardiac muscle tissue development; determination of left/right symmetry; inner ear morphogenesis; positive regulation of cell population proliferation; bone development; motor neuron axon guidance; positive regulation of cell division; embryonic hindlimb morphogenesis; phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-3-phosphate biosynthetic process; peptidyl-tyrosine phosphorylation; positive regulation of cell differentiation; regulation of signaling receptor activity; positive regulation of protein kinase B signaling; positive regulation of G protein-coupled receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	2253
	14179
	ENSG00000107831
	ENSMUSG00000025219
	P55075
	P37237
	NM_001206389; NM_006119; NM_033163; NM_033164; NM_033165
NM_001166361; NM_001166362; NM_001166363; NM_010205; NM_001379139;
	NM_001379140
	NP_001193318; NP_006110; NP_149353; NP_149354; NP_149355
NP_001159833; NP_001159834; NP_001159835; NP_034335; NP_001366068;
	NP_001366069; NP_001390029
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor 8 (FGF-8) is a protein that in humans is encoded by the FGF8 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107831 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025219 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ White RA, Dowler LL, Angeloni SV, Pasztor LM, MacArthur CA (November 1995). "Assignment of FGF8 to human chromosome 10q25-q26: mutations in FGF8 may be responsible for some types of acrocephalosyndactyly linked to this region". Genomics. 30 (1): 109–11. doi:10.1006/geno.1995.0020. PMID 8595889.
^ "Entrez Gene: FGF8 fibroblast growth factor 8 (androgen-induced)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000107831 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025219 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8595889-5] White RA, Dowler LL, Angeloni SV, Pasztor LM, MacArthur CA (November 1995). "Assignment of FGF8 to human chromosome 10q25-q26: mutations in FGF8 may be responsible for some types of acrocephalosyndactyly linked to this region". Genomics. 30 (1): 109–11. doi:10.1006/geno.1995.0020. PMID 8595889.

[entrez-6] "Entrez Gene: FGF8 fibroblast growth factor 8 (androgen-induced)".

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