Fibrolamellar hepatocellular carcinoma

Fibrolamellar hepatocellular carcinoma
Other namesFHCC
Micrograph of fibrolamellar hepatocarcinoma showing the characteristic laminated fibrosis between the tumor cells with a low NC ratio. H&E stain.
SpecialtyOncology Edit this on Wikidata

Fibrolamellar carcinoma (FLC) is a rare form of carcinoma that typically affects young adults and is characterized, under the microscope, by laminated fibrous layers interspersed between the tumor cells.[1] It has been estimated that 200 new cases are diagnosed worldwide each year.[2] However, in light of recent advances in our molecular understanding, this has recently been revised to suggest it may be at least ten times more common.[3] FLC, also known as fibrolamellar hepatocellular carcinoma, is different from the more common hepatocellular carcinoma (HCC) in that it afflicts young people with normal liver function and no known risk factors.[1][2][4][5]

  1. ^ a b Torbenson, Michael (2012). "Fibrolamellar Carcinoma: 2012 Update". Scientifica. 2012: 743790. doi:10.6064/2012/743790. PMC 3820672. PMID 24278737.
  2. ^ a b O'Neill, Allison F.; Church, Alanna J.; Perez-Atayde, Antonio R.; Shaikh, Raja; Marcus, Karen J.; Vakili, Khashayar (August 2021). "Fibrolamellar carcinoma: An entity all its own". Current Problems in Cancer. 45 (4): 100770. doi:10.1016/j.currproblcancer.2021.100770. PMID 34272087. S2CID 236001418.
  3. ^ Zack, Travis; Losert, Kurt P.; Maisel, Samantha M.; Wild, Jennifer; Yaqubie, Amin; Herman, Michael; Knox, Jennifer J.; Mayer, Robert J.; Venook, Alan P.; Butte, Atul; O'Neill, Allison F.; Abou-Alfa, Ghassan K.; Gordan, John D. (23 March 2023). "Defining incidence and complications of fibrolamellar liver cancer through tiered computational analysis of clinical data". npj Precision Oncology. 7 (1): 29. doi:10.1038/s41698-023-00371-2. PMC 10034241. PMID 36959495.
  4. ^ Lalazar, Gadi; Simon, Sanford (February 2018). "Fibrolamellar Carcinoma: Recent Advances and Unresolved Questions on the Molecular Mechanisms". Seminars in Liver Disease. 38 (1): 051–059. doi:10.1055/s-0037-1621710. PMC 6020845. PMID 29471565.
  5. ^ "What is Fibrolamellar Carcinoma?". Fibrolamellar Cancer Foundation. 20 February 2021. Retrieved 2023-01-10.