Flight 63

Flight 63 may refer to:

• American Airlines flight 63, the Richard Reid 2001 failed shoe bomb attempt
• American Airlines Flight 63 (Flagship Missouri), a DC-3 that crashed outside of Centerville, Tennessee on October 15, 1943
• American Airlines Flight 63 (Flagship Ohio), a DC-3 that crashed outside of Trammel, Kentucky on July 28, 1943
• Toa Domestic Airlines Flight 63 (1971)
• STS-63 (1995) U.S. Space Shuttle mission to the Mir space station