Fluorine-19 nuclear magnetic resonance spectroscopy

A sample 19F NMR spectrum of a simple organic compound. Integrations are shown under each peak.
19F NMR spectrum of 1-bromo-3,4,5-trifluorobenzene. The expansion shows the spin–spin coupling pattern arising from the para-fluorine coupling to the 2 meta-fluorine and 2 ortho proton nuclei.

Fluorine-19 nuclear magnetic resonance spectroscopy (fluorine NMR or 19F NMR) is an analytical technique used to detect and identify fluorine-containing compounds. 19F is an important nucleus for NMR spectroscopy because of its receptivity and large chemical shift dispersion, which is greater than that for proton nuclear magnetic resonance spectroscopy.[1][2][3]

  1. ^ Claridge, Timothy (2016). High Resolution NMR Techniques in Organic Chemistry. Oxford, United Kingdom: Elsevier. pp. 428–429. ISBN 978-0-08-099986-9.
  2. ^ Martino, R.; Gilard, V.; Malet-Martino, M. (2008). NMR Spectroscopy in Pharmaceutical Analysis. Boston: Elsevier. p. 371. ISBN 978-0-444-53173-5.
  3. ^ H. Friebolin "Basic One- and Two-Dimensional NMR Spectroscopy", Wiley-VCH, Weinheim, 2011. ISBN 978-3-527-32782-9