 Fluticasone propionate (top) and salmeterol (bottom) | |
| Combination of | |
|---|---|
| Fluticasone propionate | Glucocorticoid |
| Salmeterol | Long-acting beta-adrenoceptor agonist |
| Clinical data | |
| Trade names | Advair, Seretide, Cyplos, others |
| AHFS/Drugs.com | FDA Professional Drug Information |
| MedlinePlus | a699063 |
| License data | |
| Pregnancy category |
|
| Routes of administration | Inhalation |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| KEGG | |
| (verify) | |
Fluticasone/salmeterol, sold under the brand name Advair among others, is a fixed-dose combination medication containing fluticasone propionate, an inhaled corticosteroid; and salmeterol, a long-acting beta2‑adrenergic agonist.[2][3][4] It is used in the management of asthma and chronic obstructive pulmonary disease (COPD).[4] It is used by inhaling the medication into the lungs.[4]
Common side effects include thrush, headache, and cough.[5] Serious side effects may include worsening asthma, anaphylaxis, seizures, and heart problems.[5] Safety in pregnancy and breastfeeding is unclear.[6] Fluticasone, a corticosteroid, works by decreasing inflammation while salmeterol, a long-acting beta-adrenoceptor agonist (LABA), works by activating beta-2 adrenergic receptors.[5]
The combination was approved for medical use in the United States in 2000.[5] A generic version was approved in the United States in 2019.[7] In 2022, it was the 59th most commonly prescribed medication in the United States, with more than 11 million prescriptions.[8][9]
- ^ "Seroflo Multihaler (Cipla Australia Pty Ltd)". Department of Health and Ages Care. Retrieved 1 April 2023.
- ^ a b "Advair Diskus- fluticasone propionate and salmeterol powder". DailyMed. 30 June 2023. Retrieved 8 September 2024.
- ^ a b "Advair HFA- fluticasone propionate and salmeterol xinafoate aerosol, metered". DailyMed. 23 May 2024. Retrieved 8 September 2024.
- ^ a b c British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 263–264. ISBN 9780857113382.
- ^ a b c d "Fluticasone and Salmeterol inhalation - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 4 March 2019.
- ^ "Fluticasone / salmeterol Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.
- ^ "FDA approves first generic Advair Diskus". U.S. Food and Drug Administration (FDA) (Press release). Retrieved 30 January 2019.
- ^ "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
- ^ "Fluticasone; Salmeterol Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.