Fluvastatin

Fluvastatin
Clinical data
Trade namesLescol, others
AHFS/Drugs.comMonograph
MedlinePlusa694010
Pregnancy
category
  • AU: D
Routes of
administration		By mouth (capsules, tablets)
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • CA: ℞-only
  • UK: POM (Prescription only)
  • US: ℞-only
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability24–30%[1][2]
Protein binding>98%[2]
MetabolismHepatic: CYP2C9 (75%), CYP3A4 (20%), CYP2C8 (5%)[2][3]
Elimination half-life1–3 hours (capsule), 9 hours (XR formulations)[2][3]
ExcretionFaeces (95%), urine (5%)[2]
Identifiers
  • (3R,5S,6E)-7-[3-(4-Fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.224.327 Edit this at Wikidata
Chemical and physical data
FormulaC24H26FNO4
Molar mass411.473 g·mol−1
3D model (JSmol)
  • O=C(O)C[C@H](O)C[C@H](O)/C=C/c2c(c1ccccc1n2C(C)C)c3ccc(F)cc3
  • InChI=1S/C24H26FNO4/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30)/b12-11+/t18-,19-/m1/s1 checkY
  • Key:FJLGEFLZQAZZCD-MCBHFWOFSA-N checkY
  (verify)

Fluvastatin is a member of the statin drug class, used to treat hypercholesterolemia and to prevent cardiovascular disease.

It was patented in 1982 and approved for medical use in 1994.[4] It is on the World Health Organization's List of Essential Medicines.[5]

  1. ^ Cite error: The named reference AC was invoked but never defined (see the help page).
  2. ^ a b c d e Neuvonen PJ, Backman JT, Niemi M (2008). "Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin". Clinical Pharmacokinetics. 47 (7): 463–74. doi:10.2165/00003088-200847070-00003. PMID 18563955. S2CID 11716425.
  3. ^ a b "Lescol, Lescol XR (fluvastatin) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 18 March 2014.
  4. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 472. ISBN 9783527607495.
  5. ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.