Fluxomics

Fluxomics describes the various approaches that seek to determine the rates of metabolic reactions within a biological entity.[1] While metabolomics can provide instantaneous information on the metabolites in a biological sample, metabolism is a dynamic process.[2] The significance of fluxomics is that metabolic fluxes determine the cellular phenotype.[3] It has the added advantage of being based on the metabolome which has fewer components than the genome or proteome.[4]

Fluxomics falls within the field of systems biology which developed with the appearance of high throughput technologies.[5] Systems biology recognizes the complexity of biological systems and has the broader goal of explaining and predicting this complex behavior.[2]

  1. ^ Winter, Gal; Krömer, Jens O. (2013-07-01). "Fluxomics – connecting 'omics analysis and phenotypes". Environmental Microbiology. 15 (7): 1901–1916. doi:10.1111/1462-2920.12064. ISSN 1462-2920. PMID 23279205.
  2. ^ a b Cascante, Marta; Marin, Silvia (2008-09-30). "Metabolomics and fluxomics approaches". Essays in Biochemistry. 45: 67–82. doi:10.1042/bse0450067. ISSN 0071-1365. PMID 18793124.
  3. ^ Cascante, Marta; Benito, Adrián; Mas, Igor Marín de; Centelles, Josep J.; Miranda, Anibal; Atauri, Pedro de (2014-01-01). "Fluxomics". In Orešič, Matej; Vidal-Puig, Antonio (eds.). A Systems Biology Approach to Study Metabolic Syndrome. Springer International Publishing. pp. 237–250. doi:10.1007/978-3-319-01008-3_12. ISBN 9783319010076.
  4. ^ Raamsdonk, Léonie M.; Teusink, Bas; Broadhurst, David; Zhang, Nianshu; Hayes, Andrew; Walsh, Michael C.; Berden, Jan A.; Brindle, Kevin M.; Kell, Douglas B. (2001-01-01). "A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations". Nature Biotechnology. 19 (1): 45–50. doi:10.1038/83496. ISSN 1087-0156. PMID 11135551. S2CID 15491882.
  5. ^ Aon, Miguel A.; Cortassa, Sonia (2015-07-22). "Systems Biology of the Fluxome". Processes. 3 (3): 607–618. doi:10.3390/pr3030607.