Folate receptor 1

FOLR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4KM6, 4KM7, 4KMX, 4LRH
Identifiers
Aliases	FOLR1, FBP, FOLR, Folate receptor 1, folate receptor 1 (adult), folate receptor alpha, FRalpha, NCFTD
External IDs	OMIM: 136430; MGI: 95568; HomoloGene: 7322; GeneCards: FOLR1; OMA:FOLR1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	72,196,323 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	101,519,995 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; parotid gland; ; right lung; ; lower lobe of lung; ; upper lobe of lung; ; upper lobe of left lung; ; human kidney; ; olfactory zone of nasal mucosa; ; trachea; ; bronchial epithelial cell;
	Top expressed in
	choroid plexus of fourth ventricle; ; right kidney; ; epithelium of lens; ; Epithelium of choroid plexus; ; yolk sac; ; human kidney; ; morula; ; morula; ; proximal tubule; ; parotid gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methotrexate binding; folic acid receptor activity; folic acid transmembrane transporter activity; folic acid binding; signaling receptor activity;
Cellular component	anchored component of external side of plasma membrane; extracellular region; brush border; clathrin-coated vesicle; ER to Golgi transport vesicle membrane; anchored component of membrane; Golgi membrane; nucleus; integral component of plasma membrane; apical plasma membrane; membrane; cell surface; endoplasmic reticulum membrane; brush border membrane; basolateral plasma membrane; plasma membrane; cytoplasmic vesicle; endosome; endoplasmic reticulum-Golgi intermediate compartment membrane; anchored component of plasma membrane; extracellular exosome; transport vesicle;
Biological process	receptor-mediated endocytosis; cellular response to folic acid; neural crest cell migration involved in heart formation; axon regeneration; COPII vesicle coating; endoplasmic reticulum to Golgi vesicle-mediated transport; heart looping; cardiac neural crest cell migration involved in outflow tract morphogenesis; pharyngeal arch artery morphogenesis; folic acid metabolic process; regulation of transforming growth factor beta receptor signaling pathway; response to axon injury; regulation of canonical Wnt signaling pathway; anterior neural tube closure; folic acid transport; transport; folate import across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	2348
	14275
	ENSG00000110195
	ENSMUSG00000001827
	P15328
	P35846
	NM_016730; NM_000802; NM_016724; NM_016725; NM_016729
	NM_001252552; NM_001252553; NM_001252554; NM_008034
	NP_000793; NP_057936; NP_057937; NP_057941
	NP_001239481; NP_001239482; NP_001239483; NP_032060
	Wikidata
View/Edit Human	View/Edit Mouse

Folate receptor 1 (Folate receptor alpha, FOLR1) is a protein that in humans is encoded by the FOLR1 gene.^[5]^[6]

The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000110195 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001827 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Campbell IG, Jones TA, Foulkes WD, Trowsdale J (October 1991). "Folate-binding protein is a marker for ovarian cancer". Cancer Research. 51 (19): 5329–38. PMID 1717147.
^ "Entrez Gene: FOLR1 folate receptor 1 (adult)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000110195 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001827 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1717147-5] Campbell IG, Jones TA, Foulkes WD, Trowsdale J (October 1991). "Folate-binding protein is a marker for ovarian cancer". Cancer Research. 51 (19): 5329–38. PMID 1717147.

[entrez-6] "Entrez Gene: FOLR1 folate receptor 1 (adult)".

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