Follicle-stimulating hormone receptor

FSHR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XWD, 4AY9, 4MQW
Identifiers
Aliases	FSHR, FSHR1, FSHRO, LGR1, ODG1, follicle stimulating hormone receptor
External IDs	OMIM: 136435; MGI: 95583; HomoloGene: 117; GeneCards: FSHR; OMA:FSHR - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p16.3 Start 48,962,157 bp[1] End 49,154,527 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E5 Start 89,292,380 bp[2] End 89,508,103 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle apex of heart left ovary left testis right testis muscle layer of sigmoid colon right ovary gallbladder thymus right coronary artery Top expressed in cumulus cell Sertoli cell perirhinal cortex choroid plexus of fourth ventricle entorhinal cortex extraocular muscle spermatocyte zygote oocyte primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled peptide receptor activity G protein-coupled receptor activity signal transducer activity protein-hormone receptor activity protein binding follicle-stimulating hormone receptor activity Cellular component integral component of membrane membrane integral component of plasma membrane plasma membrane intracellular anatomical structure receptor complex Biological process G protein-coupled receptor signaling pathway male gonad development adenylate cyclase-activating G protein-coupled receptor signaling pathway female gamete generation primary ovarian follicle growth regulation of protein kinase A signaling female gonad development activation of adenylate cyclase activity regulation of osteoclast differentiation spermatogenesis hormone-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade positive regulation of phosphatidylinositol 3-kinase signaling gonad development signal transduction positive regulation of adenylate cyclase activity cellular response to follicle-stimulating hormone stimulus follicle-stimulating hormone signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2492 14309 Ensembl ENSG00000170820 ENSMUSG00000032937 UniProt P23945 P35378 RefSeq (mRNA) NM_000145 NM_181446 NM_013523 RefSeq (protein) NP_000136 NP_852111 NP_038551 Location (UCSC) Chr 2: 48.96 – 49.15 Mb Chr 17: 89.29 – 89.51 Mb PubMed search [3] [4]
Wikidata
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The follicle-stimulating hormone receptor or FSH receptor (FSHR) is a transmembrane receptor that interacts with the follicle-stimulating hormone (FSH) and represents a G protein-coupled receptor (GPCR). Its activation is necessary for the hormonal functioning of FSH. FSHRs are found in the ovary, testis, and uterus.