FHA domain | |||||||||
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Identifiers | |||||||||
Symbol | FHA | ||||||||
Pfam | PF00498 | ||||||||
Pfam clan | CL0357 | ||||||||
InterPro | IPR000253 | ||||||||
PROSITE | PDOC50006 | ||||||||
SCOP2 | 1qu5 / SCOPe / SUPFAM | ||||||||
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In molecular biology, the forkhead-associated domain (FHA domain) is a phosphopeptide recognition domain found in many regulatory proteins.[1] It displays specificity for phosphothreonine-containing epitopes but will also recognise phosphotyrosine with relatively high affinity. It spans approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich, which sometimes contains small helical insertions between the loops connecting the strands.[2]
To date, genes encoding FHA-containing proteins have been identified in eubacterial, eukaryotic and archaeal genomes. The domain is present in a diverse range of proteins, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding proteins, and metabolic enzymes which partake in many different cellular processes - DNA repair, signal transduction, vesicular transport, and protein degradation are just a few examples.