Forkhead box C1

FOXC1
Identifiers
Aliases	FOXC1, ARA, FKHL7, FREAC-3, FREAC3, IGDA, IHG1, IRID1, RIEG3, forkhead box C1, ASGD3
External IDs	OMIM: 601090; MGI: 1347466; HomoloGene: 20373; GeneCards: FOXC1; OMA:FOXC1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	1,613,897 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	31,996,459 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; vena cava; ; trigeminal ganglion; ; renal medulla; ; palpebral conjunctiva; ; tibia; ; endothelial cell; ; cartilage tissue; ; nipple; ; urethra;
	Top expressed in
	parotid gland; ; lacrimal gland; ; stria vascularis; ; interatrial septum; ; calvaria; ; ascending aorta; ; paraxial mesoderm; ; conjunctival fornix; ; pulmonary valve; ; septum primum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; DNA binding, bending; transcription coactivator binding; transcription coactivator activity; transcription factor binding; promoter-specific chromatin binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; nucleus; cytosol;
Biological process	eye development; somitogenesis; Notch signaling pathway; skeletal system development; glycosaminoglycan metabolic process; positive regulation of hematopoietic progenitor cell differentiation; regulation of transcription, DNA-templated; neural crest cell development; paraxial mesoderm formation; ossification; vascular endothelial growth factor signaling pathway; collagen fibril organization; maintenance of lens transparency; heart morphogenesis; in utero embryonic development; cardiac muscle cell proliferation; lymph vessel development; transcription, DNA-templated; embryonic heart tube development; positive regulation of hematopoietic stem cell differentiation; odontogenesis of dentin-containing tooth; positive regulation of transcription, DNA-templated; ventricular cardiac muscle tissue morphogenesis; heart development; blood vessel remodeling; brain development; vascular endothelial growth factor receptor signaling pathway; negative regulation of lymphangiogenesis; blood vessel development; positive regulation of gene expression; mesenchymal cell differentiation; mesenchymal cell development; artery morphogenesis; ovarian follicle development; negative regulation of angiogenesis; camera-type eye development; regulation of organ growth; germ cell migration; lacrimal gland development; negative regulation of mitotic cell cycle; negative regulation of apoptotic process involved in outflow tract morphogenesis; transcription by RNA polymerase II; endochondral ossification; cell population proliferation; positive regulation of epithelial to mesenchymal transition; cell migration; positive regulation of DNA binding; positive regulation of transcription by RNA polymerase II; cellular response to epidermal growth factor stimulus; positive regulation of core promoter binding; negative regulation of transcription by RNA polymerase II; cerebellum development; positive regulation of keratinocyte differentiation; glomerular epithelium development; ureteric bud development; kidney development; chemokine-mediated signaling pathway; cellular response to chemokine; angiogenesis; multicellular organism development; regulation of transcription by RNA polymerase II; anatomical structure morphogenesis; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	2296
	17300
	ENSG00000054598
	ENSMUSG00000050295
	Q12948
	Q61572
	NM_001453
	NM_008592
	NP_001444
	NP_032618
	Wikidata
View/Edit Human	View/Edit Mouse

Forkhead box C1, also known as FOXC1, is a protein which in humans is encoded by the FOXC1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000054598 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050295 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: FOXC1 forkhead box C1".
^ Pierrou S, Hellqvist M, Samuelsson L, Enerbäck S, Carlsson P (October 1994). "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending". The EMBO Journal. 13 (20): 5002–12. doi:10.1002/j.1460-2075.1994.tb06827.x. PMC 395442. PMID 7957066.
^ Nishimura DY, Swiderski RE, Alward WL, Searby CC, Patil SR, Bennet SR, et al. (June 1998). "The forkhead transcription factor gene FKHL7 is responsible for glaucoma phenotypes which map to 6p25". Nature Genetics. 19 (2): 140–7. doi:10.1038/493. PMID 9620769. S2CID 34692231.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000054598 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050295 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FOXC1 forkhead box C1".

[pmid7957066-6] Pierrou S, Hellqvist M, Samuelsson L, Enerbäck S, Carlsson P (October 1994). "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending". The EMBO Journal. 13 (20): 5002–12. doi:10.1002/j.1460-2075.1994.tb06827.x. PMC 395442. PMID 7957066.

[pmid9620769-7] Nishimura DY, Swiderski RE, Alward WL, Searby CC, Patil SR, Bennet SR, et al. (June 1998). "The forkhead transcription factor gene FKHL7 is responsible for glaucoma phenotypes which map to 6p25". Nature Genetics. 19 (2): 140–7. doi:10.1038/493. PMID 9620769. S2CID 34692231.

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