Forkhead box d1

FOXD1
Identifiers
Aliases	FOXD1, FKHL8, FREAC-4, FREAC4, forkhead box D1
External IDs	OMIM: 601091; MGI: 1347463; HomoloGene: 3290; GeneCards: FOXD1; OMA:FOXD1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q13.2 Start 73,444,827 bp[1] End 73,448,777 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia sural nerve trigeminal ganglion cartilage tissue spinal ganglia retinal pigment epithelium gonad stromal cell of endometrium testicle metanephros n/a More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription factor activity DNA binding, bending RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated branching involved in ureteric bud morphogenesis kidney development transcription by RNA polymerase II axon guidance positive regulation of gene expression positive regulation of BMP signaling pathway luteinizing hormone secretion negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II dichotomous subdivision of terminal units involved in ureteric bud branching nephrogenic mesenchyme development metanephric nephron development metanephric capsule development metanephric capsule specification pattern specification involved in metanephros development positive regulation of kidney development anatomical structure morphogenesis cell differentiation regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2297 15229 Ensembl ENSG00000251493 n/a UniProt Q16676 Q61345 RefSeq (mRNA) NM_004472 NM_008242 RefSeq (protein) NP_004463 NP_032268 Location (UCSC) Chr 5: 73.44 – 73.45 Mb n/a PubMed search [2] [3]
Wikidata
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Forkhead box D1 is a protein that in humans is encoded by the FOXD1 gene.^[4] Forkhead d1 is a kidney expressed transcription factor maps at the chromosome 5 at position 5q12—q13, identified in Drosophila forkhead protein and mammalian HNF3 transcription factor.^[5] The name of the protein was derived from two spiked head structures in the embryos of Drosophila forkhead mutant.^[5] It belongs to the transcription factor family, that displays remarkable functional diversity and is involved in a wide variety of biological processes.^[5] The most commonly used synonyms for Forkhead D1 are, FOX D1, FREAC-4 and BF2.^[5]