Forkhead box protein O1

FOXO1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CO6, 3CO7, 3COA, 4LG0
Identifiers
Aliases	FOXO1, FKH1, FKHR, FOXO1A, forkhead box O1
External IDs	OMIM: 136533; MGI: 1890077; HomoloGene: 1527; GeneCards: FOXO1; OMA:FOXO1 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.11 Start 40,555,667 bp[1] End 40,666,641 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 C|3 23.19 cM Start 52,175,757 bp[2] End 52,260,642 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua synovial joint synovial membrane pericardium middle frontal gyrus left ovary right ovary tendon of biceps brachii Achilles tendon myometrium Top expressed in secondary oocyte molar primary oocyte zygote dorsal striatum aortic valve ascending aorta lymph node Paneth cell vestibular membrane of cochlear duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding beta-catenin binding DNA-binding transcription factor activity transcription factor binding chromatin binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding protein phosphatase 2A binding ubiquitin protein ligase binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription coactivator binding Cellular component cytoplasm cytosol nucleoplasm mitochondrion nucleus Biological process insulin receptor signaling pathway negative regulation of fat cell differentiation regulation of transcription, DNA-templated positive regulation of protein catabolic process glucose homeostasis positive regulation of autophagy cellular glucose homeostasis cellular response to hyperoxia regulation of transcription by RNA polymerase II cellular response to starvation negative regulation of apoptotic process negative regulation of transcription by RNA polymerase II regulation of reactive oxygen species metabolic process transcription, DNA-templated regulation of neural precursor cell proliferation cellular response to dexamethasone stimulus cellular response to DNA damage stimulus neuronal stem cell population maintenance autophagy positive regulation of transcription, DNA-templated response to insulin blood vessel development cellular response to cold response to fluoride regulation of cell population proliferation cellular response to insulin stimulus positive regulation of apoptotic process negative regulation of stress-activated MAPK cascade cellular response to oxidative stress enamel mineralization cellular response to nitric oxide positive regulation of gluconeogenesis temperature homeostasis negative regulation of transcription, DNA-templated fat cell differentiation negative regulation of canonical Wnt signaling pathway endocrine pancreas development protein acetylation positive regulation of transcription by RNA polymerase II cellular response to hydrogen peroxide apoptotic process anatomical structure morphogenesis cell differentiation negative regulation of cardiac muscle hypertrophy in response to stress cytokine-mediated signaling pathway energy homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2308 56458 Ensembl ENSG00000150907 ENSMUSG00000044167 UniProt Q12778 Q9R1E0 RefSeq (mRNA) NM_002015 NM_019739 RefSeq (protein) NP_002006 NP_062713 Location (UCSC) Chr 13: 40.56 – 40.67 Mb Chr 3: 52.18 – 52.26 Mb PubMed search [3] [4]
Wikidata
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Forkhead box protein O1 (FOXO1), also known as forkhead in rhabdomyosarcoma (FKHR), is a protein that in humans is encoded by the FOXO1 gene.^[5] FOXO1 is a transcription factor that plays important roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling, and is also central to the decision for a preadipocyte to commit to adipogenesis.^[6] It is primarily regulated through phosphorylation on multiple residues; its transcriptional activity is dependent on its phosphorylation state.^[7][8]