The formyl peptide receptors (FPR) belong to a class of G protein-coupled receptors involved in chemotaxis.[1][2] In humans, there are three formyl peptide receptor isoforms, each encoded by a separate gene that are named FPR1, FPR2, and FPR3.[1] These receptors were originally identified by their ability to bind N-formyl peptides such as N-formylmethionine produced by the degradation of either bacterial or host cells.[3][4] Hence formyl peptide receptors are involved in mediating immune cell response to infection. These receptors may also act to suppress the immune system under certain conditions.[5] The close phylogenetic relation of signaling in chemotaxis and olfaction was recently proved by detection formyl peptide receptor like proteins as a distinct family of vomeronasal organ chemosensors in mice.[6][7]
^Braun MC, Wang JM, Lahey E, Rabin RL, Kelsall BL (Jun 2001). "Activation of the formyl peptide receptor by the HIV-derived peptide T-20 suppresses interleukin-12 p70 production by human monocytes". Blood. 97 (11): 3531–6. doi:10.1182/blood.V97.11.3531. PMID11369647.