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Franciscus Cornelis Marie (Frans) Wijffels (10 April 1899, Stratum – 22 March 1968, Delft) was a Dutch politician of the Roman Catholic State Party (RKSP) and its successor the Catholic People's Party (KVP).
Wijffels was Minister of Social Affairs in the third Gerbrandy cabinet and also a member of the House of Representatives and the Senate.