Frizzled-1

FZD1
Identifiers
Aliases	FZD1, frizzled class receptor 1
External IDs	OMIM: 603408; MGI: 1196625; HomoloGene: 20750; GeneCards: FZD1; OMA:FZD1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	91,271,326 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	4,808,035 bp
RNA expression pattern
	Top expressed in
	lactiferous duct; ; visceral pleura; ; tail of epididymis; ; tendon of biceps brachii; ; Epithelium of choroid plexus; ; parietal pleura; ; trigeminal ganglion; ; superficial temporal artery; ; hair follicle; ; spinal ganglia;
	Top expressed in
	gastrula; ; calvaria; ; vas deferens; ; umbilical cord; ; habenula; ; hair follicle; ; aortic valve; ; decidua; ; ascending aorta; ; endocardial cushion;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	PDZ domain binding; frizzled binding; signal transducer activity; Wnt-protein binding; protein binding; Wnt-activated receptor activity; signaling receptor binding; transmembrane signaling receptor activity; G protein-coupled receptor activity;
Cellular component	Wnt signalosome; membrane; focal adhesion; plasma membrane; cell surface; integral component of membrane;
Biological process	G protein-coupled receptor signaling pathway; positive regulation of protein phosphorylation; autocrine signaling; epithelial cell differentiation; muscular septum morphogenesis; ventricular septum morphogenesis; cell-cell signaling; membranous septum morphogenesis; outflow tract morphogenesis; positive regulation of DNA-binding transcription factor activity; Wnt signaling pathway; planar cell polarity pathway involved in neural tube closure; negative regulation of BMP signaling pathway; positive regulation of transcription, DNA-templated; multicellular organism development; cell surface receptor signaling pathway; canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation; canonical Wnt signaling pathway involved in osteoblast differentiation; hard palate development; neuron differentiation; canonical Wnt signaling pathway; negative regulation of transcription, DNA-templated; signal transduction; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; beta-catenin destruction complex disassembly; Wnt signaling pathway, planar cell polarity pathway; presynapse assembly; negative regulation of oxidative stress-induced neuron death; non-canonical Wnt signaling pathway; positive regulation of neuron projection development; negative regulation of canonical Wnt signaling pathway; regulation of presynapse assembly;
	Sources:Amigo / QuickGO
Orthologs
	8321
	14362
	ENSG00000157240
	ENSMUSG00000044674
	Q9UP38
	O70421
	NM_003505
	NM_021457
	NP_003496
	NP_067432
	Wikidata
View/Edit Human	View/Edit Mouse

Frizzled-1 (Fz-1) is a protein that in humans is encoded by the FZD1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000157240 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044674 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sagara N, Toda G, Hirai M, Terada M, Katoh M (Nov 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochemical and Biophysical Research Communications. 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155.
^ "Entrez Gene: FZD1 frizzled homolog 1 (Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000157240 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044674 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9813155-5] Sagara N, Toda G, Hirai M, Terada M, Katoh M (Nov 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochemical and Biophysical Research Communications. 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155.

[entrez-6] "Entrez Gene: FZD1 frizzled homolog 1 (Drosophila)".

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