Frizzled-5

FZD5
Identifiers
Aliases	FZD5, C2orf31, HFZ5, frizzled class receptor 5
External IDs	OMIM: 601723; MGI: 108571; HomoloGene: 2590; GeneCards: FZD5; OMA:FZD5 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	207,769,906 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	64,776,910 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of sigmoid colon; ; lower lobe of lung; ; mucosa of ileum; ; duodenum; ; mucosa of transverse colon; ; palpebral conjunctiva; ; kidney tubule; ; visceral pleura; ; tibia;
	Top expressed in
	median eminence; ; hair follicle; ; epithelium of small intestine; ; epithelium of stomach; ; ciliary body; ; left colon; ; arcuate nucleus; ; Paneth cell; ; calvaria; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	amyloid-beta binding; signal transducer activity; Wnt-protein binding; protein binding; protein kinase binding; ubiquitin protein ligase binding; transmembrane signaling receptor activity; Wnt-activated receptor activity; G protein-coupled receptor activity;
Cellular component	clathrin-coated endocytic vesicle membrane; Golgi apparatus; early endosome membrane; membrane; bicellular tight junction; Golgi membrane; plasma membrane; cell surface; early endosome; perinuclear region of cytoplasm; integral component of membrane;
Biological process	G protein-coupled receptor signaling pathway; T cell differentiation in thymus; chorionic trophoblast cell differentiation; positive regulation of protein targeting to mitochondrion; positive regulation of JUN kinase activity; apoptotic process involved in morphogenesis; regulation of chorionic trophoblast cell proliferation; regulation of bicellular tight junction assembly; regulation of canonical Wnt signaling pathway; cellular response to molecule of bacterial origin; positive regulation of interferon-gamma production; embryonic axis specification; labyrinthine layer blood vessel development; cell maturation; Wnt signaling pathway; embryonic camera-type eye development; multicellular organism development; cell surface receptor signaling pathway; vasculature development; regulation of autophagy of mitochondrion; branching involved in labyrinthine layer morphogenesis; embryonic camera-type eye morphogenesis; post-embryonic camera-type eye development; positive regulation of T cell cytokine production; angiogenesis; neuron differentiation; Wnt signaling pathway involved in dorsal/ventral axis specification; canonical Wnt signaling pathway; synapse assembly; syncytiotrophoblast cell differentiation involved in labyrinthine layer development; anterior/posterior axis specification, embryo; Spemann organizer formation; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; signal transduction; Wnt signaling pathway, calcium modulating pathway; Wnt signaling pathway, planar cell polarity pathway; beta-catenin destruction complex disassembly;
	Sources:Amigo / QuickGO
Orthologs
	7855
	14367
	ENSG00000163251
	ENSMUSG00000045005
	Q13467
	Q9EQD0
	NM_030804; NM_003468
	NM_001033193; NM_001042659; NM_022721
	NP_003459
	NP_001036124; NP_073558
	Wikidata
View/Edit Human	View/Edit Mouse

Frizzled-5 (Fz-5) is a protein that in humans is encoded by the FZD5 gene.^[5]^[6]^[7]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. Fz-5 is believed to be the receptor for the Wnt5A ligand.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163251 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045005 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Jun 1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". J Biol Chem. 271 (8): 4468–76. doi:10.1074/jbc.271.8.4468. PMID 8626800.
^ Saitoh T, Hirai M, Katoh M (Jun 2001). "Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region". Int J Oncol. 19 (1): 105–10. doi:10.3892/ijo.19.1.105. PMID 11408929.
^ ^a ^b "Entrez Gene: FZD5 frizzled homolog 5 (Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163251 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045005 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8626800-5] Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Jun 1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". J Biol Chem. 271 (8): 4468–76. doi:10.1074/jbc.271.8.4468. PMID 8626800.

[pmid11408929-6] Saitoh T, Hirai M, Katoh M (Jun 2001). "Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region". Int J Oncol. 19 (1): 105–10. doi:10.3892/ijo.19.1.105. PMID 11408929.

[entrez-7] "Entrez Gene: FZD5 frizzled homolog 5 (Drosophila)".

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