Furin

FURIN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4OMC, 4OMD, 4RYD, 4Z2A
Identifiers
Aliases	FURIN, FUR, PACE, PCSK3, SPC1, furin, paired basic amino acid cleaving enzyme
External IDs	OMIM: 136950; MGI: 97513; HomoloGene: 1930; GeneCards: FURIN; OMA:FURIN - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q26.1 Start 90,868,588 bp[1] End 90,883,458 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 D2|7 45.65 cM Start 80,038,333 bp[2] End 80,055,184 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver body of pancreas right lung right lobe of thyroid gland left lobe of thyroid gland apex of heart skin of leg upper lobe of left lung salivary gland anterior pituitary Top expressed in epithelium of stomach Ileal epithelium parotid gland granulocyte lip right kidney lactiferous gland corneal stroma extensor digitorum longus muscle secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nerve growth factor binding peptide binding metal ion binding protease binding peptidase activity protein binding serine-type endopeptidase inhibitor activity serine-type peptidase activity hydrolase activity endopeptidase activity serine-type endopeptidase activity Cellular component integral component of membrane Golgi apparatus membrane plasma membrane cell surface trans-Golgi network endoplasmic reticulum Golgi lumen membrane raft trans-Golgi network transport vesicle extracellular exosome extracellular space Golgi membrane extracellular region endosome endosome membrane integral component of Golgi membrane Biological process negative regulation of low-density lipoprotein particle receptor catabolic process negative regulation of transforming growth factor beta1 production viral life cycle secretion by cell peptide biosynthetic process protein processing positive regulation of membrane protein ectodomain proteolysis extracellular matrix disassembly extracellular matrix organization viral protein processing proteolysis signal peptide processing peptide hormone processing regulation of signal transduction regulation of protein catabolic process collagen catabolic process negative regulation of nerve growth factor production nerve growth factor processing nerve growth factor production cell population proliferation transforming growth factor beta receptor signaling pathway regulation of endopeptidase activity negative regulation of endopeptidase activity cornification zymogen activation regulation of lipoprotein lipase activity dibasic protein processing zymogen inhibition positive regulation of transforming growth factor beta1 activation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5045 18550 Ensembl ENSG00000140564 ENSMUSG00000030530 UniProt P09958 P23188 RefSeq (mRNA) NM_002569 NM_001289823 NM_001289824 NM_001081454 NM_011046 RefSeq (protein) NP_001276752 NP_001276753 NP_002560 NP_001369548 NP_001369549 NP_001369550 NP_001369551 NP_001276752.1 NP_001276753.1 NP_002560.1 NP_001074923 NP_035176 Location (UCSC) Chr 15: 90.87 – 90.88 Mb Chr 7: 80.04 – 80.06 Mb PubMed search [3] [4]
Wikidata
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Furin is a protease, a proteolytic enzyme activated by substrate presentation that in humans and other animals is encoded by the FURIN gene. Some proteins are inactive when they are first synthesized, and must have sections removed in order to become active. Furin cleaves these sections and activates the proteins.^[5][6][7][8] It was named furin because it was in the upstream region of an oncogene known as FES. The gene was known as FUR (FES Upstream Region) and therefore the protein was named furin. Furin is also known as PACE (Paired basic Amino acid Cleaving Enzyme). A member of family S8, furin is a subtilisin-like peptidase.