GABA receptor agonist

Gamma-aminobutyric acid, a GABA-B receptor agonist.

A GABA receptor agonist is a drug that is an agonist for one or more of the GABA receptors, producing typically sedative effects, and may also cause other effects such as anxiolytic, anticonvulsant, and muscle relaxant effects.[1] There are three receptors of the gamma-aminobutyric acid. The two receptors GABA-α and GABA-ρ are ion channels that are permeable to chloride ions which reduces neuronal excitability. The GABA-β receptor belongs to the class of G-Protein coupled receptors that inhibit adenylyl cyclase, therefore leading to decreased cyclic adenosine monophosphate (cAMP). GABA-α and GABA-ρ receptors produce sedative and hypnotic effects and have anti-convulsion properties. GABA-β receptors also produce similar effects. Furthermore, they lead to changes in gene transcription, and are mainly found in autonomic nervous system centers.

  1. ^ Brohan J, Goudra BG (October 2017). "The Role of GABA Receptor Agonists in Anesthesia and Sedation". CNS Drugs. 31 (10): 845–856. doi:10.1007/s40263-017-0463-7. PMID 29039138. S2CID 207486777.