GABRB1

GABRB1
Identifiers
Aliases	GABRB1, gamma-aminobutyric acid type A receptor beta1 subunit, EIEE45, gamma-aminobutyric acid type A receptor subunit beta1, DEE45
External IDs	OMIM: 137190; MGI: 95619; HomoloGene: 20221; GeneCards: GABRB1; OMA:GABRB1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	47,426,447 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	72,306,380 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; entorhinal cortex; ; pars reticulata; ; dorsal motor nucleus of vagus nerve; ; parietal lobe; ; endothelial cell; ; postcentral gyrus; ; Region I of hippocampus proper; ; pars compacta;
	Top expressed in
	CA3 field; ; nucleus of stria terminalis; ; subiculum; ; paraventricular nucleus of hypothalamus; ; substantia nigra; ; ventromedial nucleus; ; anterior amygdaloid area; ; medial dorsal nucleus; ; lateral hypothalamus; ; Region I of hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	anion channel activity; ion channel activity; chloride channel activity; extracellular ligand-gated ion channel activity; ligand-gated ion channel activity; GABA-gated chloride ion channel activity; GABA-A receptor activity; transmembrane signaling receptor activity; GABA receptor binding; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	cytoplasm; integral component of membrane; postsynaptic membrane; nuclear envelope; membrane; receptor complex; synapse; integral component of plasma membrane; chloride channel complex; cell junction; dendrite; nucleus; plasma membrane; GABA-A receptor complex; neuron projection; GABA-ergic synapse;
Biological process	cellular response to histamine; response to progesterone; ion transport; central nervous system neuron development; ovulation cycle; chloride transport; response to toxic substance; signal transduction; chloride transmembrane transport; gamma-aminobutyric acid signaling pathway; ion transmembrane transport; chemical synaptic transmission; regulation of membrane potential; nervous system process; regulation of postsynaptic membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	2560
	14400
	ENSG00000163288
	ENSMUSG00000029212
	P18505
	P50571
	NM_000812
	NM_008069; NM_001370968
	NP_000803
	NP_032095; NP_001357897
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-aminobutyric acid receptor subunit beta-1 is a protein that in humans is encoded by the GABRB1 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163288 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029212 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163288 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029212 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1".

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