GABRD

GABRD
Identifiers
Aliases	GABRD, EIG10, EJM7, GEFSP5, gamma-aminobutyric acid type A receptor delta subunit, gamma-aminobutyric acid type A receptor subunit delta
External IDs	OMIM: 137163; MGI: 95622; HomoloGene: 55489; GeneCards: GABRD; OMA:GABRD - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	2,030,758 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	155,482,569 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; cerebellar vermis; ; paraflocculus of cerebellum; ; prefrontal cortex; ; primary visual cortex; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	cerebellar cortex; ; lobe of cerebellum; ; cerebellar vermis; ; superior frontal gyrus; ; dorsal striatum; ; lateral geniculate nucleus; ; olfactory tubercle; ; primary visual cortex; ; nucleus accumbens; ; medial dorsal nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; chloride channel activity; extracellular ligand-gated ion channel activity; GABA-A receptor activity; ion channel activity; transmembrane signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	chloride channel complex; integral component of membrane; cell junction; GABA-A receptor complex; postsynaptic membrane; plasma membrane; synapse; integral component of plasma membrane; membrane; glutamatergic synapse; GABA-ergic synapse; integral component of postsynaptic membrane; neuron projection;
Biological process	ion transmembrane transport; chloride transport; chloride transmembrane transport; ion transport; chemical synaptic transmission; signal transduction; regulation of membrane potential; nervous system process; regulation of postsynaptic membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	2563
	14403
	ENSG00000187730
	ENSMUSG00000029054
	O14764
	P22933
	NM_000815
	NM_008072
	NP_000806
	NP_032098
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-aminobutyric acid receptor subunit delta is a protein that in humans is encoded by the GABRD gene.^[5]^[6]^[7] In the mammalian brain, the delta (δ) subunit forms specific GABA_A receptor subtypes by co-assembly leading to δ subunit containing GABA_A receptors (δ-GABA_A receptors).^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000187730 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029054 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sommer B, Poustka A, Spurr NK, Seeburg PH (October 1990). "The murine GABAA receptor delta-subunit gene: structure and assignment to human chromosome 1". DNA and Cell Biology. 9 (8): 561–568. doi:10.1089/dna.1990.9.561. PMID 2176788.
^ Emberger W, Windpassinger C, Petek E, Kroisel PM, Wagner K (Sep 2000). "Assignment of the human GABAA receptor delta-subunit gene (GABRD) to chromosome band 1p36.3 distal to marker NIB1364 by radiation hybrid mapping". Cytogenetics and Cell Genetics. 89 (3–4): 281–282. doi:10.1159/000015636. PMID 10965146. S2CID 83974022.
^ "Entrez Gene: GABRD gamma-aminobutyric acid (GABA) A receptor, delta".
^ Arslan A (March 2021). "Extrasynaptic δ-subunit containing GABA_A receptors". Journal of Integrative Neuroscience. 20 (1): 173–184. doi:10.31083/j.jin.2021.01.284. PMID 33834705. S2CID 233193240.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000187730 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029054 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2176788-5] Sommer B, Poustka A, Spurr NK, Seeburg PH (October 1990). "The murine GABAA receptor delta-subunit gene: structure and assignment to human chromosome 1". DNA and Cell Biology. 9 (8): 561–568. doi:10.1089/dna.1990.9.561. PMID 2176788.

[pmid10965146-6] Emberger W, Windpassinger C, Petek E, Kroisel PM, Wagner K (Sep 2000). "Assignment of the human GABAA receptor delta-subunit gene (GABRD) to chromosome band 1p36.3 distal to marker NIB1364 by radiation hybrid mapping". Cytogenetics and Cell Genetics. 89 (3–4): 281–282. doi:10.1159/000015636. PMID 10965146. S2CID 83974022.

[entrez-7] "Entrez Gene: GABRD gamma-aminobutyric acid (GABA) A receptor, delta".

[Arslan_2021-8] Arslan A (March 2021). "Extrasynaptic δ-subunit containing GABA_A receptors". Journal of Integrative Neuroscience. 20 (1): 173–184. doi:10.31083/j.jin.2021.01.284. PMID 33834705. S2CID 233193240.

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