Growth arrest and DNA-damage-inducible protein GADD45 gamma is a protein that in humans is encoded by the GADD45Ggene on chromosome 9. GADD45G is also known as CR6, DDIT2, GRP17, OIG37, and GADD45gamma.[5] GADD45G is involved in several different processes, including sexual development,[6] human-specific brain development,[7] tumor suppression,[8] and the cellular stress response.[9] GADD45G interacts with several other proteins that are involved in DNA repair, cell cycle control, apoptosis, and senescence.[6] Low expression of GADD45G has been associated with many types of cancer.[10]
^Zhang L, Yang Z, Ma A, Qu Y, Xia S, Xu D, Ge C, Qiu B, Xia Q, Li J, Liu Y (January 2014). "Growth arrest and DNA damage 45G down-regulation contributes to Janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma". Hepatology. 59 (1): 178–89. doi:10.1002/hep.26628. PMID23897841. S2CID39582166.