GADD45G

GADD45G
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WAL, 3FFM
Identifiers
Aliases	GADD45G, CR6, DDIT2, GADD45gamma, GRP17, growth arrest and DNA damage inducible gamma
External IDs	OMIM: 604949; MGI: 1346325; HomoloGene: 21334; GeneCards: GADD45G; OMA:GADD45G - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	89,606,555 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	52,002,504 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; right auricle; ; right lobe of liver; ; right adrenal cortex; ; left adrenal cortex; ; popliteal artery; ; tibial arteries; ; canal of the cervix; ; gastrocnemius muscle; ; muscle of thigh;
	Top expressed in
	ventricular zone; ; decidua; ; saccule; ; muscle of thigh; ; granulocyte; ; islet of Langerhans; ; gastrula; ; sternocleidomastoid muscle; ; endothelial cell of lymphatic vessel; ; digastric muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	nucleus; cytoplasm;
Biological process	positive regulation of JNK cascade; multicellular organism development; positive regulation of apoptotic process; response to stress; cell differentiation; positive regulation of p38MAPK cascade; apoptotic process; regulation of cell cycle; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	10912
	23882
	ENSG00000130222
	ENSMUSG00000021453
	O95257
	Q9Z111; Q9R0S0
	NM_006705
	NM_011817
	NP_006696
	NP_035947
	Wikidata
View/Edit Human	View/Edit Mouse

Growth arrest and DNA-damage-inducible protein GADD45 gamma is a protein that in humans is encoded by the GADD45G gene on chromosome 9. GADD45G is also known as CR6, DDIT2, GRP17, OIG37, and GADD45gamma.^[5] GADD45G is involved in several different processes, including sexual development,^[6] human-specific brain development,^[7] tumor suppression,^[8] and the cellular stress response.^[9] GADD45G interacts with several other proteins that are involved in DNA repair, cell cycle control, apoptosis, and senescence.^[6] Low expression of GADD45G has been associated with many types of cancer.^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130222 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021453 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Suzuki M, Watanabe TK, Fujiwara T, Takahashi E, Tanigami A (Oct 1999). "Molecular cloning, expression, and mapping of a novel human cDNA, GRP17, highly homologous to human gadd45 and murine MyD118". J Hum Genet. 44 (5): 300–3. doi:10.1007/s100380050164. PMID 10496071.
^ ^a ^b Johnen H, González-Silva L, Carramolino L, Flores JM, Torres M, Salvador JM (2013). "Gadd45g is essential for primary sex determination, male fertility and testis development". PLOS ONE. 8 (3): e58751. Bibcode:2013PLoSO...858751J. doi:10.1371/journal.pone.0058751. PMC 3596291. PMID 23516551.
^ McLean CY, Reno PL, Pollen AA, Bassan AI, Capellini TD, Guenther C, Indjeian VB, Lim X, Menke DB, Schaar BT, Wenger AM, Bejerano G, Kingsley DM (March 2011). "Human-specific loss of regulatory DNA and the evolution of human-specific traits". Nature. 471 (7337): 216–9. Bibcode:2011Natur.471..216M. doi:10.1038/nature09774. PMC 3071156. PMID 21390129.
^ Tamura RE, de Vasconcellos JF, Sarkar D, Libermann TA, Fisher PB, Zerbini LF (June 2012). "GADD45 proteins: central players in tumorigenesis". Curr. Mol. Med. 12 (5): 634–51. doi:10.2174/156652412800619978. PMC 3797964. PMID 22515981.
^ Liebermann DA, Hoffman B (2007). "Gadd45 in the response of hematopoietic cells to genotoxic stress". Blood Cells Mol. Dis. 39 (3): 329–35. doi:10.1016/j.bcmd.2007.06.006. PMC 3268059. PMID 17659913.
^ Zhang L, Yang Z, Ma A, Qu Y, Xia S, Xu D, Ge C, Qiu B, Xia Q, Li J, Liu Y (January 2014). "Growth arrest and DNA damage 45G down-regulation contributes to Janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma". Hepatology. 59 (1): 178–89. doi:10.1002/hep.26628. PMID 23897841. S2CID 39582166.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130222 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021453 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10496071-5] Suzuki M, Watanabe TK, Fujiwara T, Takahashi E, Tanigami A (Oct 1999). "Molecular cloning, expression, and mapping of a novel human cDNA, GRP17, highly homologous to human gadd45 and murine MyD118". J Hum Genet. 44 (5): 300–3. doi:10.1007/s100380050164. PMID 10496071.

[Johnen_2013-6] Johnen H, González-Silva L, Carramolino L, Flores JM, Torres M, Salvador JM (2013). "Gadd45g is essential for primary sex determination, male fertility and testis development". PLOS ONE. 8 (3): e58751. Bibcode:2013PLoSO...858751J. doi:10.1371/journal.pone.0058751. PMC 3596291. PMID 23516551.

[McLean_CY,_Reno_PL,_Pollen_AA,_et_al._2011_216–9-7] McLean CY, Reno PL, Pollen AA, Bassan AI, Capellini TD, Guenther C, Indjeian VB, Lim X, Menke DB, Schaar BT, Wenger AM, Bejerano G, Kingsley DM (March 2011). "Human-specific loss of regulatory DNA and the evolution of human-specific traits". Nature. 471 (7337): 216–9. Bibcode:2011Natur.471..216M. doi:10.1038/nature09774. PMC 3071156. PMID 21390129.

[Tamura-8] Tamura RE, de Vasconcellos JF, Sarkar D, Libermann TA, Fisher PB, Zerbini LF (June 2012). "GADD45 proteins: central players in tumorigenesis". Curr. Mol. Med. 12 (5): 634–51. doi:10.2174/156652412800619978. PMC 3797964. PMID 22515981.

[9] Liebermann DA, Hoffman B (2007). "Gadd45 in the response of hematopoietic cells to genotoxic stress". Blood Cells Mol. Dis. 39 (3): 329–35. doi:10.1016/j.bcmd.2007.06.006. PMC 3268059. PMID 17659913.

[Zhang_2014-10] Zhang L, Yang Z, Ma A, Qu Y, Xia S, Xu D, Ge C, Qiu B, Xia Q, Li J, Liu Y (January 2014). "Growth arrest and DNA damage 45G down-regulation contributes to Janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma". Hepatology. 59 (1): 178–89. doi:10.1002/hep.26628. PMID 23897841. S2CID 39582166.

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