GAT100

GAT100
Identifiers
  • 3-ethyl-5-isothiocyanato-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-carboxamide
CAS Number
ChemSpider
Chemical and physical data
FormulaC25H28N4OS
Molar mass432.59 g·mol−1
3D model (JSmol)
  • CCc1c([nH]c2ccc(cc12)N=C=S)C(=O)NCCc3ccc(cc3)N4CCCCC4
  • InChI=1S/C25H28N4OS/c1-2-21-22-16-19(27-17-31)8-11-23(22)28-24(21)25(30)26-13-12-18-6-9-20(10-7-18)29-14-4-3-5-15-29/h6-11,16,28H,2-5,12-15H2,1H3,(H,26,30)
  • Key:YIYLMDVRSNXYOT-UHFFFAOYSA-N

GAT100 is a negative allosteric modulator of the cannabinoid CB1 receptor.[1][2]

  1. ^ Kulkarni PM, Kulkarni AR, Korde A, Tichkule RB, Laprairie RB, Denovan-Wright EM, et al. (January 2016). "Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s)". Journal of Medicinal Chemistry. 59 (1): 44–60. doi:10.1021/acs.jmedchem.5b01303. PMC 4716578. PMID 26529344.
  2. ^ Laprairie RB, Kulkarni AR, Kulkarni PM, Hurst DP, Lynch D, Reggio PH, et al. (June 2016). "Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe". ACS Chemical Neuroscience. 7 (6): 776–98. doi:10.1021/acschemneuro.6b00041. PMC 5358098. PMID 27046127.