GATA3

GATA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4HC7, 4HC9, 4HCA
Identifiers
Aliases	GATA3, HDR, HDRS, GATA binding protein 3
External IDs	OMIM: 131320; MGI: 95663; HomoloGene: 1550; GeneCards: GATA3; OMA:GATA3 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p14 Start 8,045,378 bp[1] End 8,075,198 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 A1|2 6.69 cM Start 9,861,889 bp[2] End 9,894,845 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh skin of hip nipple skin of arm lactiferous duct renal medulla seminal vesicula skin of abdomen vulva corpus epididymis Top expressed in transitional epithelium of urinary bladder hair follicle medullary collecting duct seminal vesicula adrenal medulla lactiferous gland skin of back nasal cavity skin of external ear lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II transcription regulatory region sequence-specific DNA binding HMG box domain binding chromatin binding metal ion binding DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific interleukin-2 receptor binding core promoter sequence-specific DNA binding transcription cis-regulatory region binding protein dimerization activity E-box binding protein binding zinc ion binding transcription factor binding transcription coactivator activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific transcription coregulator activity Cellular component nucleus transcription regulator complex nucleoplasm Biological process negative regulation of cell population proliferation regulation of establishment of cell polarity ureteric bud formation negative regulation of cell cycle thymic T cell selection response to ethanol positive regulation of T cell differentiation erythrocyte differentiation inner ear morphogenesis cell maturation regulation of histone H3-K27 methylation cardiac right ventricle morphogenesis phosphatidylinositol 3-kinase signaling norepinephrine biosynthetic process ear development homeostasis of number of cells sympathetic nervous system development T-helper 2 cell differentiation regulation of cellular response to X-ray cell fate determination post-embryonic development cellular response to BMP stimulus mesonephros development neuron differentiation regulation of neuron apoptotic process signal transduction cellular response to cytokine stimulus cellular response to interleukin-4 T cell receptor signaling pathway neuron migration positive regulation of interleukin-5 production regulation of CD4-positive, alpha-beta T cell differentiation parathyroid gland development negative regulation of DNA demethylation positive regulation of interleukin-4 production negative regulation of mammary gland epithelial cell proliferation regulation of transcription by RNA polymerase II thymus development nervous system development otic vesicle development regulation of transcription, DNA-templated positive regulation of T-helper 2 cell cytokine production regulation of nephron tubule epithelial cell differentiation positive regulation of thyroid hormone generation lymphocyte migration negative regulation of interleukin-2 production regulation of neuron projection development uterus development axon guidance mesenchymal to epithelial transition negative regulation of cell proliferation involved in mesonephros development aortic valve morphogenesis cellular response to tumor necrosis factor negative regulation of fat cell differentiation anatomical structure morphogenesis cellular response to interferon-alpha negative regulation of transcription, DNA-templated T cell differentiation response to virus negative regulation of endothelial cell apoptotic process innate immune response canonical Wnt signaling pathway involved in metanephric kidney development positive regulation of transcription regulatory region DNA binding positive regulation of endothelial cell migration positive regulation of interleukin-13 production in utero embryonic development negative regulation of interferon-gamma production humoral immune response developmental growth kidney development positive regulation of ureteric bud formation positive regulation of gene expression mast cell differentiation positive regulation of histone H3-K9 acetylation positive regulation of cell differentiation negative regulation of transcription by RNA polymerase II male gonad development nephric duct morphogenesis ventricular septum development positive regulation of cytokine production lens development in camera-type eye negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation transcription, DNA-templated negative regulation of gene expression parathyroid hormone secretion nephric duct formation immune system process negative regulation of inflammatory response pharyngeal system development embryonic organ development response to estrogen blood coagulation negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation positive regulation of signal transduction ureter maturation positive regulation of histone H3-K14 acetylation positive regulation of transcription, DNA-templated response to gamma radiation cell morphogenesis embryonic hemopoiesis positive regulation of transcription by RNA polymerase II negative regulation of cell motility pro-T cell differentiation TOR signaling type IV hypersensitivity defense response regulation of histone H3-K4 methylation renal system development positive regulation of protein kinase B signaling cell activation chromatin remodeling T cell differentiation in thymus cochlea development transcription by RNA polymerase II protein deubiquitination anatomical structure formation involved in morphogenesis regulation of hematopoietic stem cell differentiation cytokine-mediated signaling pathway heart development animal organ morphogenesis tissue development cell development digestive tract development immune system development regulation of epithelial cell differentiation ureter morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2625 14462 Ensembl ENSG00000107485 ENSMUSG00000015619 UniProt P23771 P23772 RefSeq (mRNA) NM_001002295 NM_002051 NM_008091 NM_001355110 NM_001355111 NM_001355112 RefSeq (protein) NP_001002295 NP_002042 NP_032117 NP_001342039 NP_001342040 NP_001342041 Location (UCSC) Chr 10: 8.05 – 8.08 Mb Chr 2: 9.86 – 9.89 Mb PubMed search [3] [4]
Wikidata
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GATA3 is a transcription factor that in humans is encoded by the GATA3 gene. Studies in animal models and humans indicate that it controls the expression of a wide range of biologically and clinically important genes.^[5][6][7]

The GATA3 transcription factor is critical for the embryonic development of various tissues as well as for inflammatory and humoral immune responses and the proper functioning of the endothelium of blood vessels. GATA3 plays central role in allergy and immunity against worm infections.^[8][9] GATA3 haploinsufficiency (i.e. loss of one or the two inherited GATA3 genes) results in a congenital disorder termed the Barakat syndrome.^[10][11][12]

Current clinical and laboratory research is focusing on determining the benefits of directly or indirectly blocking the action of GATA3 in inflammatory and allergic diseases such as asthma.^[10] It is also proposed to be a clinically important marker for various types of cancer, particularly those of the breast. However, the role, if any, of GATA3 in the development of these cancers is under study and remains unclear.^[13]