GDF6

GDF6
Identifiers
Aliases	GDF6, BMP-13, BMP13, CDMP2, KFM, KFS, KFS1, KFSL, LCA17, MCOP4, MCOPCB6, SCDO4, SGM1, growth differentiation factor 6, SYNS4
External IDs	OMIM: 601147; MGI: 95689; HomoloGene: 40883; GeneCards: GDF6; OMA:GDF6 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	96,160,806 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	9,862,345 bp
RNA expression pattern
	Top expressed in
	placenta; ; gonad; ; ventricular zone; ; gallbladder; ; right auricle; ; gastric mucosa; ; right coronary artery; ; Achilles tendon; ; smooth muscle tissue; ; left coronary artery;
	Top expressed in
	auditory ossicle; ; stapes; ; incus; ; malleus; ; ganglion; ; embryo; ; Jacobson's organ; ; sensory ganglion; ; genital tubercle; ; trigeminal ganglion;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; protein homodimerization activity; transforming growth factor beta receptor binding; growth factor activity; protein binding;
Cellular component	extracellular region; extracellular space;
Biological process	regulation of apoptotic process; apoptotic process; pathway-restricted SMAD protein phosphorylation; retinal cell apoptotic process; regulation of MAPK cascade; cell development; positive regulation of pathway-restricted SMAD protein phosphorylation; BMP signaling pathway; positive regulation of transcription, DNA-templated; multicellular organism development; positive regulation of chondrocyte differentiation; positive regulation of neuron differentiation; activin receptor signaling pathway; SMAD protein signal transduction; positive regulation of p38MAPK cascade; fat cell differentiation; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	392255
	242316
	ENSG00000156466
	ENSMUSG00000051279
	Q6KF10
	P43028
	NM_001001557
	NM_013526
	NP_001001557
	NP_038554
	Wikidata
View/Edit Human	View/Edit Mouse

Growth differentiation factor 6 (GDF6) is a protein that in humans is encoded by the GDF6 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156466 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051279 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Davidson AJ, Postlethwait JH, Yan YL, Beier DR, van Doren C, Foernzler D, Celeste AJ, Crosier KE, Crosier PS (February 1999). "Isolation of zebrafish gdf7 and comparative genetic mapping of genes belonging to the growth/differentiation factor 5, 6, 7 subgroup of the TGF-beta superfamily". Genome Res. 9 (2): 121–9. doi:10.1101/gr.9.2.121. PMID 10022976.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000156466 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051279 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10022976-5] Davidson AJ, Postlethwait JH, Yan YL, Beier DR, van Doren C, Foernzler D, Celeste AJ, Crosier KE, Crosier PS (February 1999). "Isolation of zebrafish gdf7 and comparative genetic mapping of genes belonging to the growth/differentiation factor 5, 6, 7 subgroup of the TGF-beta superfamily". Genome Res. 9 (2): 121–9. doi:10.1101/gr.9.2.121. PMID 10022976.

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