GJA10

GJA10
Identifiers
Aliases	GJA10, CX62, gap junction protein alpha 10
External IDs	OMIM: 611924; MGI: 1339969; HomoloGene: 7733; GeneCards: GJA10; OMA:GJA10 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	89,921,760 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	32,602,760 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; left testis; ; right testis; ; prefrontal cortex;
	Top expressed in
	embryo; ; zygote; ; neural layer of retina; ; secondary oocyte; ; primary oocyte; ; subdivision of hippocampus; ; Region I of hippocampus proper; ; gland; ; adipose tissue; ; endocrine gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	gap junction channel activity;
Cellular component	integral component of membrane; gap junction; cell junction; plasma membrane; connexin complex; membrane;
Biological process	synapse assembly; cell communication; gamete generation; transmembrane transport; response to light stimulus; detection of light stimulus involved in visual perception;
	Sources:Amigo / QuickGO
Orthologs
	84694
	14610
	ENSG00000135355; ENSG00000288435
	ENSMUSG00000051056
	Q969M2
	Q9WUS4
	NM_032602
	NM_010289
	NP_115991
	NP_034419
	Wikidata
View/Edit Human	View/Edit Mouse

Gap junction alpha-10 protein, also known as connexin-62 (Cx62), is a protein that in humans is encoded by the GJA10 gene.^[5]

Connexins, such as GJA10, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits.^[5]^[6]

^ ^a ^b ^c ENSG00000288435 GRCh38: Ensembl release 89: ENSG00000135355, ENSG00000288435 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051056 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: gap junction protein".
^ Söhl G, Nielsen PA, Eiberger J, Willecke K (2003). "Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues". Cell Commun. Adhes. 10 (1): 27–36. doi:10.1080/15419060302063. PMID 12881038. S2CID 225894.

[refGRCh38Ensembl-1] ENSG00000288435 GRCh38: Ensembl release 89: ENSG00000135355, ENSG00000288435 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051056 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: gap junction protein".

[pmid12881038-6] Söhl G, Nielsen PA, Eiberger J, Willecke K (2003). "Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues". Cell Commun. Adhes. 10 (1): 27–36. doi:10.1080/15419060302063. PMID 12881038. S2CID 225894.

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