GLI1

GLI1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GLI, 4BLB, 4KMD
Identifiers
Aliases	GLI1, GLI, GLI family zinc finger 1, PAPA8, PPD1
External IDs	OMIM: 165220; MGI: 95727; HomoloGene: 3859; GeneCards: GLI1; OMA:GLI1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.3 Start 57,459,785 bp[1] End 57,472,268 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 D3|10 74.5 cM Start 127,165,751 bp[2] End 127,177,843 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibial nerve sural nerve gastric mucosa canal of the cervix testicle dorsal motor nucleus of vagus nerve rectum blood gonad stromal cell of endometrium Top expressed in spermatogonium tooth molar Gonadal ridge lip genital tubercle dermis palate epithelium of seminiferous tubule of testis lower jaw More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding microtubule binding chromatin binding metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding nucleic acid binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm cytosol cilium nucleoplasm ciliary base ciliary tip axoneme nucleus Biological process epidermal cell differentiation proximal/distal pattern formation cell differentiation pituitary gland development regulation of transcription, DNA-templated positive regulation of smoothened signaling pathway lung development positive regulation of cell migration smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation notochord regression transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of DNA replication ventral midline development multicellular organism development regulation of smoothened signaling pathway liver regeneration response to wounding regulation of osteoblast differentiation osteoblast differentiation spermatogenesis positive regulation of cell population proliferation cerebellar cortex morphogenesis regulation of hepatocyte proliferation canonical Wnt signaling pathway smoothened signaling pathway dorsal/ventral pattern formation negative regulation of canonical Wnt signaling pathway positive regulation of transcription by RNA polymerase II digestive tract morphogenesis prostate gland development positive regulation of cardiac muscle cell proliferation positive regulation of cell cycle G1/S phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2735 14632 Ensembl ENSG00000111087 ENSMUSG00000025407 UniProt P08151 P47806 RefSeq (mRNA) NM_001160045 NM_001167609 NM_005269 NM_010296 RefSeq (protein) NP_001153517 NP_001161081 NP_005260 NP_034426 Location (UCSC) Chr 12: 57.46 – 57.47 Mb Chr 10: 127.17 – 127.18 Mb PubMed search [3] [4]
Wikidata
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Zinc finger protein GLI1 also known as glioma-associated oncogene is a protein that in humans is encoded by the GLI1 gene. It was originally isolated from human glioblastoma cells.^[5]